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Currently, clinical outcomes using chimeric-antigen receptors (CARs) show great promise against hematological malignancies. However, due to the re-emergence of antigen-positive or negative cells, it is common for these CARs to observe relapses after treatment. Therefore, improvements in developing CAR designs that target loss of target antigens and increase the persistence of effector cells represent a critical need.
Dual targeting provides more comprehensive ablation and overcomes the pitfalls of single-antigen therapy by preventing relapses due to antigen loss. Here, Creative Biolabs has developed an innovative anti-tumor activity compound CAR, possessing two complete and independent CAR receptors against two different antigens, thereby addressing a major obstacle to this emerging therapeutic class.
Compound CAR Design
The compound CAR we developed can simultaneously express two scFv anibody domains and target two different tumor antigens. Hence, cCAR includes two discrete CAR units: anti - antigen1 and anti - antigen2 CAR, which linked by a self-cleaving P2A peptide thus expressing both functional CAR molecules on the T-cell surface.
The dual targeting mechanism exhibits potent and specific anti-tumor activity and may increase the persistence of effector cells by preventing relapse due to antigen loss.
Fig.1 Schematic representation of cCAR.
Read more:
www.nature.com/articles/leu2017302
www.nature.com/articles/s41375-018-0075-3
For more detailed information, please feel free to contact us or directly sent us an inquiry.
Reference
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