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Logic-gated CARs represent a sophisticated evolution of the conventional CAR-T therapy. These CARs are engineered with advanced molecular switches, allowing them to be activated in a controlled and precisely regulated manner. At Creative Biolabs, our Logic-Gated CAR Construction Service leverages these state-of-the-art advancements to create tailored solutions for our clients.
1. AND-Gate CARs
AND-Gate CARs require the presence of multiple antigens to trigger T-cell activation. These CARs demand the simultaneous engagement of two or more antigenic targets, effectively enhancing the specificity of target recognition. This is particularly advantageous in scenarios where single-antigen targeting might lead to therapy escape due to antigen loss.
Figure 1 Schematic representation of selected logic AND gate strategies.1
2. OR-Gate CARs
In contrast, OR-Gate CARs are designed to activate T-cells when they encounter any one of the multiple target antigens. This flexible approach ensures that the CAR-T cells remain active as long as they identify at least one antigen, making them adaptable to the heterogeneity of tumor cell populations.
Figure 2 Schematic representation of selected logic OR gate strategies.2
3. NOT-Gate CARs
NOT-Gate CARs operate inversely by suppressing T-cell activity upon recognizing specific antigens. This design can be valuable in mitigating the adverse effects of CAR-T therapy on healthy tissues, reducing toxicity, and enhancing safety profiles.
Figure 3 Schematic representation of selected logic NOT gate strategies.1
At Creative Biolabs, we understand the importance of flexibility in CAR-T therapy. With our team of expert scientists and cutting-edge technologies, we can tailor Logic-gated CARs to your exact specifications. Whether you require a unique Boolean logic configuration or want to incorporate additional safety features, our service ensures that your CAR-T therapy aligns perfectly with your patients' needs.
References
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