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B Cell Maturation Antigen (BCMA), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17),is encoded by TNFRSF17 gene in human. It is a transmembrane signaling protein preferentially expressed on plasma cells. It is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). Its ligands including BAFF and A Proliferation Inducing Ligand (APRIL). BCMA is involved in JNK and NF-kB activation pathways that induce B-cell development and autoimmune responses. BCMA has been implicated in autoimmune disorders as well as B-lymphocyte malignancies, leukemia, lymphomas, and multiple myeloma.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-T-1-L335-2 | Anti-BCMA scFv h(CD28) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD28 | Lentiviral | T cell | ||
| CAR-T-1-L335-G | Anti-BCMA scFv h(FcεRIγ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-1-L335-Z | Anti-BCMA scFv h(CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L335-2G | Anti-BCMA scFv h(CD28-FcεRIγ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD28-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-L335-2Z | Anti-BCMA scFv h(CD28-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L335-4G | Anti-BCMA scFv h(CD4-FcεRIγ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD4-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-L335-4Z | Anti-BCMA scFv h(CD4-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD4-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L335-8Z | Anti-BCMA scFv h(CD8-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD8-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L335-BZ | Anti-BCMA scFv h(41BB-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-LC002 | Anti-BCMA (J6M0)h(41BB-CD3ζ) CAR, pCDCAR1 | Human | J6M0 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-LC041 | Anti-BCMA (C12A3.2) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | C12A3.2 | Mouse | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-LC042 | Anti-BCMA (C11D5.3) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | C11D5.3 | Mouse | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-LC043 | Anti-BCMA (C11D5.3) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | C11D5.3 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-LC135 | Anti-BCMA (P5A2) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | P5A2 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-LC260 | Anti-BCMA (C12A3.2) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | C12A3.2 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-LC261 | Anti-BCMA (BC50) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | BC50 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-LC262 | Anti-BCMA (BC30) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | BC30 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-MZ014 | Anti-BCMA (XR79) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | XR79 | Humanized | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CARP-LX-001 | Anti-BCMA h(28ζ) CART, Combined with Bb007, a CAR Plus System | Human | CD28-CD3ζ | Lentiviral vector | |||||
| CARP-LX-045 | Anti-BCMA h(BBζ) CART, Combined with Bb007, a CAR Plus System | Human | 41BB-CD3ζ | Lentiviral vector | |||||
| XS-0823-LX2 | Anti-hBCMA (AB) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | AB | Adenoviral vectors |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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