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LeY represents lewis antigen. The Lewis antigen system is a human blood group system based upon genes on chromosome 19 p13.3 (FUT3 or Lewis gene) and 19q13.3, (FUT2 or secretor gene). Both genes are expressed in glandular epithelia and have dominant alleles (Le and Se, respectively) coding for enzymes with fucosyltransferase activity and recessive alleles (le and se, respectively) that are not functional. There are two main types of Lewis antigens, Lewis a (Le-a) and Lewis b (Le-b). There are three common phenotypes: Le(a+b-), Le(a-b+), and Le(a-b-). They are red cell antigens which are not produced by the erythrocyte itself. Instead, Lewis antigens are components of exocrine epithelial secretions, and are subsequently adsorbed onto the surface of the erythrocyte. The Le(b) and H antigens are receptors for the bacteria Helicobacter pylori, a gram-negative bacterium that can cause gastritis and has been implicated in peptic ulcer disease, gastric adenocarcinoma, mucosa-associated lymphoma (or mucosal associated lymphatic tissue lymphoma- MALToma) and idiopathic thrombocytopenic purpura (ITP).
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-SB-LX0317 | Anti-LeY (MB 314) h(CD28-CD3ζ) CAR, pSBCAR1 | Human | MB 314 | Human | scFv-CD28-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-LX0318 | Anti-LeY (BR55-2) h(CD28-CD3ζ) CAR, pSBCAR1 | Human | BR55-2 | Mouse | scFv-CD28-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-LX0321 | Anti-LeY (MB311) h(CD28-CD3ζ) CAR, pSBCAR1 | Human | MB311 | Human | scFv-CD28-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| XS-0822-YF613 | Anti-Human LeY (XW-613) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-613 | Human | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF614 | Anti-Human LeY (XW-614) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-614 | Human | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF615 | Anti-Human LeY (XW-615) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-615 | Human | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF619 | Anti-Human LeY (XW-619) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-619 | Human | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF620 | Anti-Mouse LeY (XW-620) m(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-620 | Rat | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1533 | Anti-Human LeY (XW-613) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-613 | Human | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1534 | Anti-Human LeY (XW-614) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-614 | Human | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1535 | Anti-Human LeY (XW-615) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-615 | Human | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1536 | Anti-Human LeY (XW-616) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-616 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1537 | Anti-Human LeY (XW-617) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-617 | Human | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1538 | Anti-Human LeY (XW-618) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-618 | Human | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1539 | Anti-Human LeY (XW-619) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-619 | Human | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1540 | Anti-Mouse LeY (XW-620) m(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-620 | Rat | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF8429 | TS-Fluc Anti-Human LeY scFv (XW-613) CD28-CD3ζ CAR, pCDCAR1 | Human | XW-613 | Human | 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ | Lentiviral vector |
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