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NKG2D

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Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1122-YF4269 Anti-NKG2D TCR-ABR (scFv-CD3δ, XW-589) CAR Plasmid, pCDCAR1 Mouse XW-589 Rat scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4270 Anti-NKG2D TCR-ABR (scFv-CD3δ, XW-590) CAR Plasmid, pCDCAR1 Mouse XW-590 Hamster scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4271 Anti-NKG2D TCR-ABR (scFv-CD3δ, XW-591) CAR Plasmid, pCDCAR1 Mouse XW-591 Hamster scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4272 Anti-NKG2D TCR-ABR (scFv-CD3δ, XW-592) CAR Plasmid, pCDCAR1 Mouse XW-592 Rat scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF5187 Anti-NKG2D TCR-ABR (scFv-CD3ε, XW-587) CAR Plasmid, pCDCAR1 Human XW-587 Human scFv-CD3ε Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF5188 Anti-NKG2D TCR-ABR (scFv-CD3ε, XW-588) CAR Plasmid, pCDCAR1 Human XW-588 Human scFv-CD3ε Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF6111 Anti-NKG2D (XW-591) h(CD28-CD3ζ) CAR, pAAV Mouse XW-591 Hamster scFv-CD28-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-1122-YF6112 Anti-NKG2D (XW-592) h(CD28-CD3ζ) CAR, pAAV Mouse XW-592 Rat scFv-CD28-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-0123-ZP96 Anti-NKG2D (KYK-2.0) h(scFv-CD3ε) TRuC, pCDTRC1 Human KYK-2.0 Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP97 Anti-NKG2D (KYK-1.0) h(scFv-CD3ε) TRuC, pCDTRC1 Human KYK-1.0 Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP461 Anti-NKG2D (MI6) h(scFv-CD3ε) TRuC, pCDTRC1 Mouse MI6 Rat scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP462 Anti-NKG2D (MAB0840) h(scFv-CD3ε) TRuC, pCDTRC1 Mouse MAB0840 Hamster scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP463 Anti-NKG2D (HMG2D) h(scFv-CD3ε) TRuC, pCDTRC1 Mouse HMG2D Hamster scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP464 Anti-NKG2D (CX5) h(scFv-CD3ε) TRuC, pCDTRC1 Mouse CX5 Rat scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0323-ZP96 Anti-NKG2D (KYK-2.0 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Human KYK-2.0 Human scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
XS-0323-ZP97 Anti-NKG2D (KYK-1.0 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Human KYK-1.0 Human scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
XS-0323-ZP461 Anti-NKG2D (MI6 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Mouse MI6 Rat scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
XS-0323-ZP462 Anti-NKG2D (MAB0840 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Mouse MAB0840 Hamster scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
XS-0323-ZP463 Anti-NKG2D (HMG2D scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Mouse HMG2D Hamster scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
XS-0323-ZP464 Anti-NKG2D (CX5 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Mouse CX5 Rat scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
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