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Tyrosine-protein kinase transmembrane receptor ROR1, also called neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), belongs to the receptor tyrosine kinase-like orphan receptor (ROR) subfamily. It is a type I membrane protein, which is regulating neurite growth in the central nervous system. ROR1 is playing a functional role in the activity of ovarian cancer cells, and associated with B-cell chronic lymphocytic leukaemia.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| XS-0323-LX3957 | TRAC-ROR1 (X3XT159) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT159 | Humanized | Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX3958 | TRAC-ROR1 (X3XT160) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT160 | Humanized | Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX3959 | TRAC-ROR1 (X3XT161) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT161 | Humanized | Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX3960 | TRAC-ROR1 (X3XT162) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT162 | Humanized | Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX3961 | TRAC-ROR1 (X3XT163) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT163 | Humanized | Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4192 | TRAC-ROR1 (X3XT152) h(CD28-OX40-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT152 | Human | Homology arm-EF1a-scFv-CD28-OX40-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4193 | TRAC-ROR1 (X3XT153) h(CD28-OX40-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT153 | Human | Homology arm-EF1a-scFv-CD28-OX40-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4434 | TRAC-ROR1 (X3XT152) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT152 | Human | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4435 | TRAC-ROR1 (X3XT153) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT153 | Human | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4436 | TRAC-ROR1 (X3XT154) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT154 | Human | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4437 | TRAC-ROR1 (X3XT155) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT155 | Human | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4438 | TRAC-ROR1 (X3XT156) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT156 | Humanized | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4439 | TRAC-ROR1 (X3XT157) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT157 | Humanized | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4440 | TRAC-ROR1 (X3XT158) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT158 | Humanized | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4441 | TRAC-ROR1 (X3XT159) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT159 | Humanized | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4442 | TRAC-ROR1 (X3XT160) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT160 | Humanized | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4443 | TRAC-ROR1 (X3XT161) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT161 | Humanized | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4444 | TRAC-ROR1 (X3XT162) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT162 | Humanized | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4445 | TRAC-ROR1 (X3XT163) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT163 | Humanized | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0823-LX87 | Anti-hROR1 (12) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | 12 | Adenoviral vectors | |||||
| XS-0923-LX114 | Anti-hROR1 (CD28-41BB-CD3ζ) CAR-duplex CTLA4 pCDCAR1 Vector | Human | X9X-83 | scFv-CD28-41BB-CD3ζ-duplex CTLA4 | Lentiviral vector | T cell | CAR-T |
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