anti-AFP TCR, pSFG(TCR-L001)

The vector of anti-AFP T cell receptor (TCR) is constructed for the engineering of T cell to target Human AFP. The T cells are genetically modified through transduction with a retroviral vector expressing AFP-specific T cell receptor. And the vector product was designed for the treatment of Liver tumor .


Details


Target
AFP
Target Species
Human
Epitope
AFP[158-166]
Format
Non-modified TCR
HLA
HLA-A2
Targeting Diseases
Liver tumor
Vector Name
pSFG
Vector Length
8200bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
alpha fetoprotein
Official Symbol
AFP
Gene ID
UniProt ID
Synonyms
AFPD; FETA; HPAFP; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Liver tumor
Introduction
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Fax: 1-631-207-8356
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