anti-pp65 TCR, pMP71(TCR-L094)

The vector of anti-pp65 T cell receptor (TCR) is constructed for the engineering of T cell to target Cytomegalovirus (CMV) pp65. The T cells are genetically modified through transduction with a retroviral vector expressing pp65-specific T cell receptor. And the vector product was designed for the treatment of CMV disease.


Details


Target
pp65
Target Species
Cytomegalovirus (CMV)
Epitope
NLVPMVATV
Format
Non-modified TCR
Targeting Diseases
CMV disease
Vector Name
pMP71
Vector Length
3817bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
pp65 protein
Official Symbol
pp65
Synonyms
65 kDa matrix phosphoprotein; 65 kDa phosphoprotein; Tegument protein pp65; Tegument protein UL83; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Cytomegalovirus infection
Introduction
Cytomegalovirus is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella zoster virus (which causes chicken pox), and Epstein Barr virus (which causes infectious mononucleosis). These viruses share a characteristic ability to remain dormant within the body over a long period. CMV viral genes are co-ordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to the commencement of viral DNA replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viral antigens may be demonstrated in the nuclei and cytoplasm of infected cells. pp65 is a 65kD phosphorylated glycoprotein and is the most abundant of the late antigens.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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