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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The risk of on-target/off-tumor toxicity is a major obstacle for the development of effective CAR T cell therapies. Strategies to minimize the "on-target/off-tumor" toxicity by improving the specific tumor recognition have to be developed, especially for targeting TAAs that are self-antigens and differentially expressed by tumor cells.
The combinatorial CAR is desighed by recognizing two different antigens on the tumor cells via engineering T cells with two CAR molecules: one CAR provides only the activation signal (the same as the first-generation CAR) and the other CAR provides co-stimulation (similar to the second-generation CAR but only has a co-stimulatory moiety, not an activation moiety). Therefore, optimal and effective T cell activation can only be achieved by the recognition of two different antigens simultaneously on the tumor cells, while sparing normal tissue that may only express one of these two antigens.
There are currently no customer reviews or questions for CAR1(CD19 scFv-41BB), CAR2(Igκ scFv-CD3ζ), a Combinatorial CAR (CAR-NR-ZP2481). Click the button below to contact us or submit your feedback about this product.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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