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CAR-T immunotherapy is a robust treatment strategy for hematologic malignancies with dramatic anti-tumor efficacy. However, the expansion and trafficking rate of CAR-T cells are often insufficient to produce long-term remission, and serious CRS toxicities may occur after administration. The imaging platform development for CAR-T cell expansion and trafficking visualization will provide a promising approach to monitor inadequate response and act as an early warning for CAR-T toxicity, allowing CAR-T therapy to be tailored accordingly to maximize therapeutic efficiency.
Fig.1 The schematic of in vivo CAR-T imaging.1
To this end, Creative Biolabs is committed to providing comprehensive CAR-T imaging services for global customers to facilitate the tracking of CAR-T cells in vivo. Our services cover non-specific strategies to visualize activated T cells and robust reporter systems to specifically monitor engineered T cells. These approaches are expected to provide valuable information and guidance to improve CAR-T therapy.
Our CAR-T imaging services cover a variety of non-specific approaches to detect activated T cells, and many robust reporter systems to specifically monitor engineered T cells, including but not limited to the following sections:
Non-specific CAR-T Imaging Service of Activated T cells:
In vivo activated T cell imaging utilizing surface activation markers:
CD25, OX40, PD-1, CTLA-4, Granzyme B, IFN-γ;
In vivo activated T cell imaging utilizing metabolic pathways kinase:
Deoxycytidine kinase (dCK), Deoxyguanosine kinase (dGK);
In vivo activated T cell imaging utilizing T cell-specific surface markers:
TCR, CD3, CD4, CD8;
Specific CAR-T Imaging Service using Reporter Genes:
Herpes simplex virus 1 thymidine kinase (HSV-tk);
Sodium iodide symporter (NIS);
Somatostatin receptor type 2 (SSTr2);
Human deoxycytidine kinase (hdCK);
In vivo CAR-T imaging with nanoparticle labeling
Fig.2 Photoacoustic images of CAR-T cells visualization labeled with ferumoxytol.2
Q1: What is the significance of CAR-T imaging development?
A1: As CAR-T therapy continues to become an important means of cancer treatment, there will be an urgent need to develop several appropriate imaging platforms to allow non-invasive imaging and monitoring of the expansion and trafficking rate of CAR-T cells in vivo. CAR-T cell dynamics visualization is of great significance in studying the interaction between T cells and cancer cells, as well as several normal tissues.
Q2: What criteria should an ideal CAR-T imaging platform meet?
A2: Such a CAR-T imaging platform meets the following criteria:
Creative Biolabs provides comprehensive in vivo CAR-T imaging services that allow for full customization and design from pilot studies to special targeted projects. If you are interested in more information about our in vivo CAR-T imaging service, please don't hesitate to contact us.
References
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