Human ROR1 CAR Detection Reagent, His Tag (CARD-LX070)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. Human ROR1 CAR Detection Reagent, His Tag is a special detection reagent which carries a polyhistidine tag at the C-terminus, and is used to detect human ROR1 CAR related to the study of Leukemia, breast cancer.

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Specifications

Target
ROR1

Application
FC

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -80°C or lower.
Please avoid repeated freeze-thaw cycles.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
Leukemia, breast cancer

Molecular Characterization
It contains AA Gln 30 - Glu 403 (Accession # Q01973-1).

Conjugation
Unconjugated

Tag
His Tag

Size
1 mg

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Form
Lyophilized

Images
Figure 1 Structure

Target

Target Introduction
Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

Target Alternative Names
Receptor tyrosine kinase like orphan receptor 1

Entrez Gene ID
4919

UniProt ID
Q01973-1

Related Resources

Overview of ROR1-Targeted CAR Cell Therapies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Human ROR1 CAR Detection Reagent, His Tag (CARD-LX070)

Specific Inquiry

Specifications

Target

Related Resources

Customer Reviews and Q&As

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