Anti-snRNP T cell receptor (H6.GWK), pCDTCR1(TCR-C235Z)

The vector of anti-snRNP T cell receptor (TCR) is constructed for the engineering of T cell to target Human snRNP. The T cells are genetically modified through transduction with a lentiviral vector expressing snRNP-specific T cell receptor. And the vector product was designed for the treatment of Mixed connective tissue disease (MCTD).


Details


Target
snRNP
Target Species
Human
Format
Non-modified
HLA
HLA-DR4
Targeting Diseases
Mixed connective tissue disease (MCTD)
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
H6.GWK
Antibody Host
Human

Target


Gene Name
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
Official Symbol
LSM2
Gene ID
Synonyms
snRNP; small nuclear ribonucleoproteins; UsnRNP; G7B; snRNP; C6orf28; YBL026W
Introduction
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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Tel: 44-207-097-1828

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