Anti-GPC T cell receptor, pCDTCR1(TCR-C087Z)

The vector of anti-GPC T cell receptor (TCR) is constructed for the engineering of T cell to target LCMV GPC. The T cells are genetically modified through transduction with a lentiviral vector expressing GPC-specific T cell receptor. And the vector product was designed for the treatment of Lymphocytic choriomeningitis virus infection.


Details


Target
GPC
Target Species
LCMV
Epitope
KAVYNFATC
Format
Non-modified
HLA
H-2Kb
Targeting Diseases
Lymphocytic choriomeningitis virus infection
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Host
Mouse

Target


Gene Name
Pre-glycoprotein polyprotein GP complex
Official Symbol
GPC
UniProt ID
Synonyms
GPC; Pre-glycoprotein polyprotein GP complex
Introduction
The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion. Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis. Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential).

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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Tel: 44-207-097-1828

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