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Anti-RPS4Y T cell receptor (YKIII.8), pCDTCR1 (TCR-C225Z)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-RPS4Y T cell receptor (TCR) is constructed for the engineering of T cell to target Human RPS4Y. The T cells are genetically modified through transduction with a lentiviral vector expressing RPS4Y-specific T cell receptor. And the vector product was designed for the treatment of Graft versus host disease (GvHD).

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Details

  • Target
  • RPS4Y
  • Target Species
  • Human
  • Epitope
  • TIRYPDPVI
  • Format
  • Non-modified
  • Allele
  • HLA-B*5201
  • Targeting Diseases
  • Graft versus host disease (GvHD)
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • TCR Clone
  • YKIII.8
  • Host Species
  • Mouse

Target

  • Official Symbol
  • RPS4Y1
  • Introduction
  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, X-linked (RPS4X). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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