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Off-Target Profiling

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The toxicity caused by off-target binding to the cell surface or secreted proteins is the main cause of drug development failure. Assessing the toxicity of drug candidates can help reduce risk through a more informed safety assessment and save significant time and resources by allowing the early failure of adverse drugs. Creative Biolabs's cell microarray screening can be applied to the understanding of the off-target binding potential of novel biopharmaceutical leads during early development. Our off-target screening data can be used to meet the regulatory submission of clinical studies, which require high confidence in the specificity of new biotherapeutics.

Off-Target Screening ServicesOff-Target Profiling

  • Assessing the off-target of plasma membranes and secreted proteins expressed in human cells
  • Provide support information for IND regulatory submissions (including US FDA, EMA, and China FDA)
  • Has a very low false positive/negative number
  • Is a supplement or replacement for tissue cross-reactivity (TCR) and immunohistochemistry studies
  • Can predict/interpret reduced bioavailability due to off-target binding
  • Can inform pre-clinical tox model selection, reduce animal testing
  • Helps prioritize drug leads or avoid off-target activity in next-generation molecules

Screening for Off-Targets of:

  • Antibody and bispecific
  • ScFv, Fab or antibody derivative
  • Whole CAR-T cell
  • Peptide
  • Protein ligand
  • Labeled small molecule

Key Features of Off-Target Screening Services

High Specificity

Surfarray™'s low false positive rate ensures that months or years of research are not wasted to chase dead ends when verifying potential target hits. Off-target screening using Surfarray™ cell microarray technology typically reports one or two confirmed interactions, rather than 100 erroneous results often seen by protein microarrays. This saves months of verification and avoids unnecessary groping, which can affect regulatory submissions.

Creative Biolabs is dedicated to helping our worldwide customers shorten the discovery and development time in CAR-T cell therapy. We utilize unrivaled, proprietary drug design, study data, product candidate, advanced project life-cycle management, as well as real-time data to ensure the ideal outcomes.

For more detailed information, please feel free to contact us or directly send us an inquiry.

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