EGFRvA

Epidermal growth factor receptor (EGFR) is a transmembrane protein that is activated by binding of its specific ligands. Epidermal growth factor receptor isoform (EGFRvA) has higher tumor-promoting capacity than EGFR. Moreover, EGFRvA is more stable than EGFR because of its decreased binding to E3 ubiquitin ligase c-CbI. EGFRvA as a drug target is associated with lung cancer, colon cancer, anal cancer, glioblastoma and epithelian tumors of the head and neck.

Associated Disease
  • Lung cancer
  • Colon cancer
  • Anal cancer
  • Glioblastoma
  • Epithelian tumors of the head and neck
  • Others
Anti-EGFRvA CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-MZ187 T cell First 2D3 ~8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-MZ188 T cell Second 2D3 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-MZ189 T cell Second 2D3 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-MZ190 T cell Third 2D3 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

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Australia
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