MDM2

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Associated Disease
  • Cancer
Anti-MDM2 TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-L070Z Human Mouse 8kb Lentiviral Non-modified HLA-A2 Inquiry
TCR-L071 Human Mouse 3111bp retroviral vector STTVTKER Non-modified TCR HLA-A2 Inquiry
TCR-L345 Human TCR 1 Mouse ~8kb Lentiviral aa 81-88 Non-modified H-2Kb Inquiry
TCR-L346 Human MDM2 Mouse ~8kb Lentiviral aa 81-88 Non-modified H-2Kb Inquiry
TCR-L347 Human 1bd2 Human ~8kb Lentiviral aa 81-88 Non-modified HLA-A2.1 Inquiry
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