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This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-ZP8586 | Anti-WT1 (Aali) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | Aali | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0622-ZP3312 | Anti-WT1 h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 | Human | VHH1-VHH2-CD28-CD3ζ | Lentiviral vector | T Cell | ||||
| XS-0622-ZP3484 | Anti-WT1 h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 | VHH1-VHH2-4-1BB-CD3ζ | Lentiviral vector | T Cell | |||||
| XS-0822-YF914 | Anti-Human WT1 (XW-914) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-914 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1834 | Anti-Human WT1 (XW-914) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-914 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2754 | Anti-Human WT1 (XW-914) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-914 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0922-ZP980 | Anti-WT1 (#213) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | #213 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-ZP1290 | Anti-WT1 (#213) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | #213 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-YF914 | Anti-WT1 KIR CAR (scFv-KIR2DS2-DAP12, XW-914), pCDCAR1 | Human | XW-914 | Mouse | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF1834 | Anti-WT1 TCR-ABR (scFv-TCRα, XW-914) CAR Plasmid, pCDCAR1 | Human | XW-914 | Mouse | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF2754 | Anti-WT1 TCR-ABR (scFv-TCRβ, XW-914) CAR Plasmid, pCDCAR1 | Human | XW-914 | Mouse | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF3674 | Anti-WT1 TCR-ABR (scFv-CD3γ, XW-914) CAR Plasmid, pCDCAR1 | Human | XW-914 | Mouse | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF4594 | Anti-WT1 TCR-ABR (scFv-CD3δ, XW-914) CAR Plasmid, pCDCAR1 | Human | XW-914 | Mouse | scFv-CD3δ | Lentiviral vector | T Cell | ||
| XS-1122-YF5514 | Anti-WT1 TCR-ABR (scFv-CD3ε, XW-914) CAR Plasmid, pCDCAR1 | Human | XW-914 | Mouse | scFv-CD3ε | Lentiviral vector | T Cell | ||
| XS-1122-YF6434 | Anti-WT1 (XW-914) h(CD28-CD3ζ) CAR, pAAV | Human | XW-914 | Mouse | scFv-CD28-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF7354 | Anti-WT1 (XW-914) h(41BB-CD3ζ) CAR, pAAV | Human | XW-914 | Mouse | scFv-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF8274 | Anti-WT1 (XW-914) h(CD28-41BB-CD3ζ) CAR, pAAV | Human | XW-914 | Mouse | scFv-CD28-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-0123-ZP635 | Anti-WT1 (#213) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | #213 | Mouse | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0323-ZP635 | Anti-WT1 (#213 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | #213 | Mouse | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0923-LX58 | Anti-hWT1 (CD28-41BB-CD3ζ) CAR-duplex CTLA4 pCDCAR1 Vector | Human | X9X-27 | scFv-CD28-41BB-CD3ζ-duplex CTLA4 | Lentiviral vector | T cell | CAR-T |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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