WT1

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Associated Disease
  • Cancer
Anti-WT1 TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-C259Z Human TAK1 Human ~8kb Lentiviral CMTWNQMNL Codon optimized HLA-A24 Inquiry
TCR-C260Z Human Human ~8kb Lentiviral RMFPNAPYL Cysteine-modified HLA-A2 Inquiry
TCR-L122Z Human Human 8kb Lentiviral RMFPNAPYL Non-modified HLA-A2 Inquiry
TCR-L123 Human Human 3817bp retroviral vector RMFPNAPYL Non-modified TCR HLA-A2 Inquiry
TCR-L123Z Human Murinized (from Human) 8kb Lentiviral RMFPNAPYL Murinized HLA-A2 Inquiry
TCR-L124 Human Murinized (from Human) 3817bp retroviral vector RMFPNAPYL Murinized TCR HLA-A2 Inquiry
TCR-L124Z Human Human 8kb Lentiviral CMTWNQMNL Non-modified HLA-A24 Inquiry
TCR-L125 Human Human 3817bp retroviral vector CMTWNQMNL Non-modified TCR HLA-A24 Inquiry
TCR-L125Z Human Human 8kb Lentiviral RMFPNAPYL Codon optimized Inquiry
TCR-L264 Human P22 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L265 Human D13 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L266 Human D13.1 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L267 Human D13.0.1 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L268 Human D13.1 .1 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L360 Human 37F8 Human ~8kb Lentiviral CMTWNQMNL Non-modified HLA-A*24:02 Inquiry
TCR-L361 Human 32F3 Murinized ~8kb Lentiviral CMTWNQMNL Non-modified HLA-A*24:02 Inquiry
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