Carbohydrate Antigen Products
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Are you currently facing challenges in identifying specific therapeutic targets, long drug development cycles, or difficulties in developing highly specific antibodies? Creative Biolabs' advanced Carbohydrate Antigen services help you accelerate target identification and obtain high-quality, highly specific anti-carbohydrate antibodies through cutting-edge glycoengineering and high-throughput screening platforms.
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Carbohydrate Antigen
A carbohydrate antigen (CA) represents an immunogenic substance structurally based on saccharide units. These molecular markers exist on cellular surfaces across healthy and malignant tissues, where they mediate intercellular communication and immunological identification. Chemically, carbohydrates constitute polyhydroxy compounds encompassing aldehydic, alcoholic, ketonic, and acidic structures with their derivatives and macromolecular assemblies, fundamentally composed of carbon, hydrogen, and oxygen atoms. Their classification by polymerization degree distinguishes three categories: monomeric sugars, short-chain oligomers, and polymeric polysaccharides. Research confirms these biomolecules' critical involvement in immune regulation, fertilization processes, hemostatic mechanisms, pathogen defense systems, and ontogenetic progression.
Fig.1 Antigen processing and presentation for different types of carbohydrate structures.1,3
Over recent decades, carbohydrate-derived biomarkers have emerged as critical diagnostic indicators and therapeutic targets in oncology. Notably, CA-125 facilitates oncogenesis and malignant proliferation through diverse molecular pathways. CA19-9 plays a pivotal role in pancreatic cancer monitoring and therapeutic evaluation, while CA15-3 serves as a principal biomarker for breast carcinoma detection and progression tracking. Additionally, CA72-4 demonstrates elevated expression across multiple adenocarcinoma subtypes, including gastrointestinal and ovarian malignancies.
CA 19-9
Carbohydrate antigen 19-9 (CA19-9), a sialylated Lewis blood group antigen, serves as a pivotal biomarker for pancreatic ductal adenocarcinoma (PDAC) due to its overexpression in malignant transformation. Clinically, it provides critical guidance for PDAC management across diagnostic stratification, therapeutic monitoring, and survival prediction. Notably, elevated CA19-9 concentrations may necessitate surgical intervention in select benign pancreatic conditions. In biliary pathology, this glycoconjugate enhances diagnostic accuracy for cholangiocarcinoma when combined with imaging modalities.
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Published Data
Fig.2 The distribution of serum CEA and CA 19-9 levels.2,3
This investigation evaluated the prognostic relevance of carbohydrate antigen 19-9 (CA19-9) in metastatic colorectal cancer (mCRC) cohorts. While CA19-9 remains a validated circulating biomarker for pancreatic cancer therapeutic monitoring, the study explored its predictive capacity in mCRC through longitudinal biomarker dynamics. Researchers conducted a retrospective cohort analysis of clinical records to quantify associations between baseline/pre-therapeutic CA19-9 concentrations and survival metrics in mCRC. The objective centered on establishing whether pretreatment biomarker thresholds or therapeutic trajectory fluctuations could function as independent prognostic indicators. Results demonstrated CA19-9's capacity to stratify metastatic progression risks, extending its clinical applicability beyond pancreatic malignancies to gastrointestinal oncology.
What We Can Offer?
Creative Biolabs is your premier partner for high-quality Carbohydrate Antigen Products, supporting your research from discovery to development. We provide a comprehensive suite of products and services designed to meet the diverse needs of the scientific community.
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Extensive Catalog of Carbohydrate Antigens: A broad selection of pre-synthesized and characterized glycans, including:
- Oligosaccharides: Defined linear and branched sugar chains.
- Monosaccharides: Fundamental sugar units for synthesis and research.
- Nucleosides: Glycosylated purine or pyrimidine bases.
- Neoglycolipids: Synthetic glycolipids with defined glycan head groups for membrane-binding studies.
- Complex Glycans: Custom-tailored multi-antennary or highly modified glycan structures.
- Cancer-Associated Glycan Antigens: A focused collection of antigens relevant to various cancers (e.g., Sialyl Lewis X, Globo H, Tn antigen) for biomarker discovery and therapeutic targeting.
- Pathogen-Associated Glycan Antigens: Antigens derived from bacteria, viruses, and fungi for infectious disease research, vaccine development, and diagnostic assays.
- Custom Carbohydrate Synthesis Services: Tailored synthesis of novel or specific glycan structures not available in our catalog, precisely to your specifications.
- Glycan Conjugation Services: Coupling of carbohydrate antigens to carrier proteins (e.g., BSA, KLH) or other molecules to enhance immunogenicity or create probes for assays.
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Why Choose Us?
Choosing Creative Biolabs for your Carbohydrate Antigen Products means partnering with a leader dedicated to advancing glycoscience. Our commitment to excellence, coupled with our deep scientific expertise, positions us as your ideal collaborator.
- Unparalleled Purity & Specificity: Our products undergo rigorous purification and characterization, ensuring the highest purity and precise structural identity for reliable and reproducible results.
- Broad Spectrum of Glycans: We offer an extensive catalog of carbohydrate antigens, including various oligosaccharides, nucleosides, monosaccharides, neoglycolipids, and complex glycans, catering to diverse research needs.
- Custom Synthesis Expertise: Beyond our catalog, we specialize in the custom synthesis of unique or difficult-to-obtain glycan structures, providing tailored solutions for your specific project.
- Integrated Solutions: Our offerings are seamlessly integrated with our anti-glycan antibody development and detection services, providing a comprehensive solution from antigen to antibody.
- Dedicated Scientific Support: Our team of experienced glycobiologists is committed to providing expert guidance and technical support throughout your project lifecycle.
FAQs
Here are some common questions from our clients interested in Carbohydrate Antigen Products:
Q: How can I be sure of the purity and structural integrity of Creative Biolabs' carbohydrate antigen products?
A: At Creative Biolabs, we employ a multi-faceted approach to ensure the highest quality. All our carbohydrate antigen products undergo rigorous analytical characterization using advanced techniques such as Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), and High-Performance Liquid Chromatography (HPLC). Each shipment comes with a detailed Certificate of Analysis (CoA) providing comprehensive purity and structural data. If you have specific purity requirements or would like to discuss our characterization methods in more detail, please don't hesitate to contact our scientific team.
Q: Can Creative Biolabs provide custom carbohydrate antigens not listed in your catalog?
A: Absolutely! Custom synthesis is one of our core strengths. If you require a unique or rare glycan structure, our expert chemists and glycobiologists are adept at synthesizing complex carbohydrate antigens tailored precisely to your specifications. Simply share your target structure or project requirements with us, and we will work with you to design a feasible and efficient synthesis strategy. Reach out to discuss your custom synthesis needs!
Q: What applications are Creative Biolabs' Carbohydrate Antigen Products best suited for?
A: Our Carbohydrate Antigen Products are incredibly versatile and are utilized across a wide range of applications. They are ideal for developing highly specific anti-glycan antibodies, establishing diagnostic assays (e.g., ELISA, glycan arrays), studying protein-glycan interactions, exploring cellular recognition events, developing vaccine candidates, and identifying novel biomarkers in cancer and infectious diseases. Let us know your research focus, and we can guide you to the most suitable products.
Related Services
To further support your research and development in glycobiology, Creative Biolabs offers a suite of related services:
Creative Biolabs offers a series of anti-glycan antibody-related services for worldwide customers. To explore these capabilities, please contact us for more information.
References:
- Kappler, Katharina, and Thierry Hennet. "Emergence and significance of carbohydrate-specific antibodies." Genes and immunity vol. 21,4 (2020): 224-239. DOI:10.1038/s41435-020-0105-9
- Thomsen, Maria et al. "Prognostic role of carcinoembryonic antigen and carbohydrate antigen 19-9 in metastatic colorectal cancer: a BRAF-mutant subset with high CA 19-9 level and poor outcome." British journal of cancer vol. 118,12 (2018): 1609-1616. DOI:10.1038/s41416-018-0115-9
- Distributed under Open Access license CC BY 4.0, without modification.
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