The anti-glycan antibody has long been an indispensable tool in assaying glycosyltransferases and glycosidases, which exert a significant role in many biological processes relevant to human health and disease. Dedicated to the research and production of antibodies many years, Creative Biolabs has gained a wealth of good reputation for successfully completed a series of challenging antibodies programs. Our well-recognized experts and professional teams are very pleased to provide one-stop or custom services of Anti-Glycan antibodies with the highest quality and the most competitive price for global clients.
Both glycosyltransferases and glycosidases are critical carbohydrate-processing enzymes involved in a number of important biological processes, such as basic formation and hydrolysis of carbohydrates, posttranslational modification of glycoproteins, and synthesis of glycosides and glycoconjugates. Detection and characterize of glycosyltransferases and glycosidases is a method for their function researches, as well as for the elucidation of the biological and functional processes of carbohydrates. Although a variety of new methods for assaying glycosyltransferase and glycosidase activity have been developed, immunological methods have long been used for product detection, among which anti-glycan antibodies were extensively utilized in various formats assaying with high specificity. Anti-glycan antibodies can be utilized as specific probes of glycosyltransferases and glycosidases assays.
For example, assay α1-3 fucosyltransferases by means of capturing of the glycosyltransferase on immobilized antibodies to antigens, or binding the anti-glycan antibodies to the immobilized fucosylated glycosyltransferase in an ELISA-type format. The detection also can be conducted by using beads containing the acceptor glycan in flow cytometry that is a modification to a new structure that can be recognized by an anti-glycan antibody. While glycosidases tests can be performed by measuring the gain in the binding of anti-glycan antibodies.
Fig.1 Examples of different uses of plant and animal lectins, carbohydrate-binding molecules (CBMs), and antibodies in glycobiology (Varki, 2015-2017).
Through hard working for several years, Creative Biolabs has successfully established several professional and state-of-the-art antibody-based platforms for different antibody services. Including anti-glycan antibodies, we are capable to provide comprehensive related services, from extensive products, Anti-glycan antibody development, Anti-glycan antibody engineering, detection services, diverse applications, to related supports, which based on as follows:
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