Based on our high-throughput anti-bacteria biomolecular discovery system, Creative Biolabs has accumulated extensive experience in the discovery of anti-chlamydia antibody and epitope identification. We are pleased to use our cutting-edge platform to offer the best service and the most qualified products to satisfy each demand from our customers.
Chlamydia are obligatory intracellular bacteria causing acute and chronic infections in animals and humans. Humans mainly contract Ch. trachomatis, Ch. pneumoniae, Ch. abortus, and Ch. psittaci. Ch. trachomatis is the world′s leading cause of preventable blindness in developing countries in North Africa and Asia. It is also a predominant pathogen in sexually transmitted urogenital infections in developed countries and is considered as the major cause of secondary infertility in women resulting from tubal damage and occlusion. Reactive arthritis is another syndrome resulting from primary genital Ch. trachomatis infection. Ch. pneumoniae is a pathogen of the respiratory tract with which more than half of the adult population is infected in different geographic areas all over the world. It is well established that the infection is usually mild in immunocompetent hosts, but severe pneumonias are observed in immunocompromised patients. Antibodies with high specificity and affinity have been selected to various molecular components associated with chlamydia and proved useful in a variety of analytical methods.
Chlamydial LPS exhibits low endotoxic activity. LPS is attributed to the higher hydrophobicity of its lipid A moiety with fatty acids of longer chain length and the presence of non-hydroxylated fatty acids ester-linked to the sugar backbone. Chlamydial LPS also harbors a genus-specific epitope composed of a 3-deoxy-D-manno-oct-2-ulopyranosonic acid (Kdo) trisaccharide with the sequence Kdoα2→8Kdoα2→4Kdoα2→, which is surface-exposed and highly immunogenic.
The elementary body is the nonreplicating infectious particle that is released when infected cells rupture. It is responsible for the bacteria's ability to spread from person to person and is analogous to a spore. The surface molecules of infectious chlamydial EBs play essential roles in pathogenesis and virulence as they are probably represented in the initial interface for interactions with host systems, including the immune system and infection of target host cells. There is a need to develop clonal reagents for diagnostic assays, purification and molecular characterization of molecules on the surfaces of microbial pathogens.
Creative Biolabs has established a high-throughput AntInfect™ Platform for biomolecular development against infectives. Our scientists have accumulated extensive experience in the development of antibodies against diverse species of chlamydia. Based on our advanced phage display technologies, the epitope for monoclonal antibodies against chlamydia or patient serum with chlamydia infection can be identified by screening our phage display peptide libraries with different properties.
In addition, we offer neutralizing antibody and peptide discovery services for multiple viruses, as well as antibody/peptide discovery for parasites. We offer turn-key or ala carte services customized to our client’s needs. Please contact us for more information and a detailed quote.
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