Equipped with the world-leading technology and knowledge, Creative Biolabs is able to offer the best service for the discovery of antibodies and peptides targeting Mycobacterium for global customers. We are excellent partner in developing Mycobacterium-specific agents that meet your clinical and research applications.
Mycobacterium tuberculosis (MTB) is a cause of Tuberculosis (TB) which is one of the most important infectious diseases in humans and leads to huge costs in both health and financial terms. It is reported by World Health Organization (WHO) that MTB infects one third of the global population, causing more than 8 million cases and 1.8 million deaths, 450,000 of whom are children. Furthermore, antibiotic resistance in MTB is a very serious and growing challenge. Multidrug-resistant tuberculosis requires long-term treatment with expensive and often toxic drugs, and treatment is commonly failed. As thus, the early diagnosis and treatment of TB patients are essential for the control of this disease. Currently, development of antibodies and antibacterial peptides targeting MTB is a promising strategy for controlling MTB infection.
CD1b-Ac2SGL complex is formed through CD1b molecules presenting MTB lipids to the immune system in MTB-infected cells. Due to the lack of CD1b polymorphism, specific MTB lipid-CD1b complex could be used as a universal marker for MTB infection. Camacho et al. (2016) have identified a single, light-variable domain antibody (dAbκ11) that showed high relative binding to the Ac2SGL-CD1b complex. dAbκ11 was selected from a synthetic human scFv phage antibody library by using Ac2SGL-CD1b as the target.
Fig.1 Human antibody-displaying phages recognizing CD1b-Ac2SGL on CD1b-transfected THP-1 cells (Camacho et al. 2016).
MTB heat shock protein 16.3 (HSP16.3) is a small heat shock protein, required for the replication of TB in host macrophage cells. This protein is a latency-associated antigen that can be targeted for TB diagnostic and therapeutic development. Ag85B is a 30 kDa major secretory protein of MTB. It is a potent immunoprotective antigen and regarded as a leading drug target. A study has indicated that the Ag85B-Hsp16.3 fusion protein, expressed and purified from a prokaryotic system, is used as the antigen to generate a monoclonal antibody that may be valuable for the diagnosis of TB.
In recent years, a number of studies have shown that natural antimycobacterial peptides can disrupt the function of the mycobacterial cell wall through different ways of action and then interact with intracellular targets including nucleic acids, enzymes and even organelles. More importantly, the probability of anti-bacterial resistance is very low. Creative Biolabs has been working in the field of discovery of peptides with anti-bacterial activities for many years. Based on the advanced technologies, such as construction of natural peptide library, screening peptide targeting MTB based on phage display or peptide array, we are capable of selecting the high-quality anti-MTB peptides.
With the years of experience in the field of antibody/peptide discovery and engineering, Creative Biolabs is very proud of providing one-stop services to help you discover high-quality antibodies and peptides targeting MTB in an effective and low-cost manner. Anti-Bacteria Biomolecular Discovery is a powerful platform that is optimal for discovery of antibodies and peptides targeting MTB. If you are interested in our services, please don't hesitate to contact us for more information and a detailed quote.
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