MUC16 Assay Portfolio Service
Introduction What We Can Offer Workflow Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
Creative Biolabs' service is designed to deliver specific, actionable solutions for your research. Creative Biolabs provides assays that can distinguish between the shed MUC16-Nter and the biologically significant cell-associated MUC16-Cter fragments, addressing a key challenge in MUC16-based therapeutic development. This precision allows you to confidently assess biomarker status, monitor treatment response, and investigate key protein interactions, such as the MUC16-mesothelin axis, with confidence.
MUC16 as a Biomarker of Disease
MUC16 (CA125) is a high molecular weight mucin glycoprotein and a key biomarker for ovarian cancer. Its complex structure, including a cleavage site that produces cell-associated (C-ter) and shed (N-ter) forms, poses measurement challenges. The cell-associated C-terminal fragment's role in cellular signaling and its interaction with mesothelin are now known to drive tumor growth and metastasis.
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Fig.1 Structure diagram of MUC16.1
What We Can Offer
Comprehensive Functional Assays
We offer a suite of functional assays to investigate MUC16's biological role in tumor growth and metastasis. These include assays for cell proliferation (CCK8, MTT), migration and invasion, and apoptosis.
Advanced Protein Analysis Platforms
Our technologies include sensitive ELISA for quantification, western blotting and immunoprecipitation to confirm expression and molecular weight, and flow cytometry and immunohistochemistry for single-cell and spatial analysis.
Specialized Interaction and Barrier Function Studies
We provide specialized assays to explore MUC16's cellular interactions. This includes the MUC16-mesothelin binding assay, critical for studying ovarian cancer metastasis, and barrier function assays to investigate MUC16's protective role.
Custom Assay Development
For unique research needs, our custom assay development service creates bespoke solutions. We can design new antibody pairs, optimize protocols for challenging samples, and target unique epitopes or post-translational modifications relevant to your hypothesis.
Highlights
Unrivaled Scientific Expertise
We design assays that provide precise, context-rich data, helping researchers differentiate between various protein forms. We proactively troubleshoot issues and deliver more reliable results than standard methods.
Advanced Technological Platforms
We use cutting-edge, high-throughput platforms optimized for exceptional sensitivity and specificity. These technologies overcome assay variability and matrix interference, allowing you to accelerate your research without compromising data quality.
Commitment to Data Precision and Reliability
We ensure data precision through rigorous quality control, from antibody selection to final data analysis. Every assay is meticulously validated to be reproducible, scientifically sound, giving you confidence in your findings.
Tailored Solutions for Your Research
We offer a collaborative, custom assay development service that partners with you to create bespoke solutions. We precisely match our services to your unique project goals.
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Customer Reviews
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Data Reliability & Consistency
Creative Biolabs' service has significantly improved our biomarker data reproducibility and consistency. The reliability of their data has been a game-changer, overcoming the inconsistencies of off-the-shelf kits. - L. M. *u*ller.
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Custom Assay Excellence
We struggled to find a commercial kit for a novel MUC16 epitope. Creative Biolabs' service was a game-changer, designing and validating an assay that perfectly fit our needs. This solution allowed us to pursue a unique research hypothesis. - D. M. *s*on.
FAQs
Can your service help with my MUC16-mesothelin interaction studies?
Yes, our advanced assays are designed for complex protein interactions like the MUC16-mesothelin binding. We can help you quantitatively assess binding affinity, screen for inhibitors, and evaluate therapeutic candidates' impact on this key pathway.
What kind of samples can you analyze?
We've validated our assays for human serum, plasma, and cell culture supernatants. We also offer custom solutions for challenging matrices like tissue lysates or ascites fluid, working with you to ensure reliable results.
How do you ensure the quality and reliability of your MUC16 assay data?
We follow a rigorous quality control protocol from antibody selection to final data analysis. Our assays are meticulously validated using stringent controls and internal standards to ensure high reproducibility and accuracy.
Related Services
Protein Purification
We can express and purify specific domains of the MUC16 protein, such as the extracellular domains or the C-terminal tail, to meet your precise research requirements.
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Biomarker Development Service
Utilizing advanced proteomic screening and bioinformatics, we can help you identify novel protein biomarkers that correlate with disease progression.
Learn More →
How to Contact Us
Creative Biolabs is ready to assist you. Don't hesitate to reach out and speak with one of our expert scientists about your project. We're here to help you navigate the complexities of MUC16 research, explore our full portfolio of services, and find the perfect, customized solution to meet your specific research needs. To begin your partnership with us, contact us now.
Reference
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Zhang, Xin-Yu, Lian-Lian Hong, and Zhi-qiang Ling. "MUC16: clinical targets with great potential." Clinical and experimental medicine 24.1 (2024): 101. Distributed under an Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.1007/s10238-024-01365-5
For Research Use Only | Not For Clinical Use
