To make go or no-go decisions at different stages of drug discovery and development, the quality, sensitivity and accuracy of biomarkers are critical to help us make smart decisions. Creative Biolabs is dedicated to biomarker identification, assay development and validation services to provide our clients with the key information that could help move your research forward.
Biomarker analysis and analytical readouts are critical in drug discovery and development, ranging from target validation studies to lead optimization and candidate selection. Hence, the biomarker development to measure the accuracy and sensitivity is necessary for making critical go or no-go decisions. With extensive experience in biomarker identification, assay development and sample processing, Creative Biolabs can support your drug discovery pipeline by providing biomarker development.
Fig.1 End-to-end solution for biomarker development.
To identify specific biomarker for research, we focus on genetics/genomics services using state-of-the-art technologies (such as sequencing, mass spectrometry and real time PCR) and equipment.
We offer a broad range of specific analytical services using our platforms such as ELISA, EIA, Western blotting, HPLC. For assays, we provide the following, but not limited to them.
| Determination of Nitrite | DA, DOPAC, HVA | CGRP | C99, C83, holoAPP | BDNF | Aβ1-40, Aβ1-42 |
| Ach | 5HT | EGF | eNOS | Eotaxin | EPO |
| F-kappaB p65 | Fractalkine | GAPDH | G-CSF | GLT-1 (GLAST) | Glutamate |
| GM-CSF | GRO/KC | IDE activity assay | IFN-γ | IGF-I | IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 (p70 or total), IL-13, IL-17A, IL-18 |
| IP-10 | KC/GRO/CINC (CXCL1) | LDH Measurement | Leptin | LIX | MCP-1 |
| MIP-1α, MIP-2 | NA | PGE2 | Protein Determination Assay | P-ser9-GSK3β | p-TAU, total TAU |
| RANTES | Synaptophysin | TGF-β | TNF-α | VEGF | |
Our senior scientists are committed to developing study-specific biomarker assays and analytical readouts for animal models. We can transfer, develop and qualify results for you. Once the assay development is completed, fast and accurate testing services can be implemented as soon as possible. The assays available include, but are not limited to the following:
| Bioanalytical immunoassays | Genetic biomarkers | Gene expression testing | Biobank resource of flash frozen samples of our in vivo portfolio available |
| Protein/phosphoprotein analysis | Plate-based apoptosis assays | Tumor profiling for target expression and modulation | Tumor sampling for in vivo pre-clinical study to monitor for target modulation |
| Cytokine analysis | Clinical biochemistry testing | Immunohistochemistry capabilities | |
Creative Biolabs offers strategic biomarker assay validation and qualification to help accurately test your samples and provide you with reliable biological translations to make smart decisions in your drug discovery. Whether the assays are performed at your facility or designed and implemented at Creative Biolabs, please feel free to contact us to tailor the best service for you.
For Research Use Only | Not For Clinical Use
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