Genetic Testing for Cancer
The occurrence of cancer is a complex process that is controlled by oncogenes and tumor suppressor genes. Certain gene mutations may cause a cell to make (or not make) proteins that affect how the cell grows and divides into new cells, further leading to cancer formation. Hence, cancer genetic detection is very significant for cancer diagnosis and prognosis. Besides, cancer genetic testing is also important for personalized medicine guidance because patients carrying different tumor gene mutations may exhibit different responses to the same anti-cancer drug.
Creative Biolabs is skilled in NGS-based cancer research. We support one-stop cancer research services based on a variety of sequencing technologies. Our whole gene sequencing (WGS) and whole exome sequencing (WES) platforms enable us to comprehensively analyze and identify known and unknown cancer gene mutations. Besides, we also provide high-quality target sequencing services, allowing us to analyze several or even hundreds of target gene mutations economically and effectively. Our services will facilitate our customers’ cancer research including cancer diagnosis and treatment.
Genetics and Cancer
Cancer is a genetic disorder that is caused by variations in certain genes or DNA fragments, which leads to uncontrolled cell growth. These genetic mutations can be inherited, and more commonly, can be acquired over time. Oncogenes and tumor suppressor genes are two of main types of genes that play a key role in cancer occurrence. Proto-oncogenes are genes that normally control cell growth and divide. Some mutations in a proto-oncogene mutates may change the gene into a "bad" gene named oncogenes, which makes the cell grows out of control and promote tumorigenesis. Most cancer-causing mutations in oncogenes are acquired, not inherited. They usually activate oncogenes through chromosome rearrangements and gene duplication. Common examples of oncogenes include ABL1, RAS, MYC, SRC, BCL2, and EGFR. Tumor suppressor genes, also known as antioncogenes, are normal genes that generate a stop signal that needs to control the cell division and act as the body’s natural army against tumor and cancer progression. But some mutations could result in a function loss of tumor suppressor genes, thus increasing the risk of tumor formation. Common examples of the tumor suppressor gene family include TP53, JAK2, NPM1, PTEN, IL2, and TCF3.
Fig. 1 Cancer and gene.
Our Capability
With our extensive experience, advanced platform, and powerful technologies, Creative Biolabs is confident in offering the most suitable sequencing and analysis solutions for cancer gene research. You can work with us to select the most appropriate detection platform, study design, and analysis options tailored to the purpose of your project. At Creative Biolabs, we guarantee the most satisfactory results for our customers all over the world, including but not limited to:
We provide a variety of pan-cancer panels that allow researchers to comprehensively analyze a series of gene mutations associated with many common cancers, including breast, colon, lung, gastric, uterine, ovarian, brain, nervous system, renal, and so on.
WGS services allow analysis of known or unknown gene mutations associated with cancer development and treatment at the genome-wide level.
WES services allow analysis of known or unknown gene mutations associated with cancer development and treatment at the exon level. Compared to WGS, WES is more economical due to it only targets exonic regions.
We support a series of targeted cancer gene panel detection services including common solid tumors and hematologic malignancies. Our services will accelerate your cancer research in a cost-effective manner.
Highlights
- Experienced scientist team providing a real-time technical guidance
- State-of-the-art and powerful sequencing technologies
- Rigorous quality control ensuring accurate and reliable data delivery
- Customizable analysis solutions to meet various needs of customers
- Fastest turnaround time to accelerate project success
If you are interested in our services, please don’t hesitate to contact us for more details. We look forward to discussing your inquiry and finding the best solution for your needs.
Reference
- Wu, S.; et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019, 575(6): 1330-1341
