Epigenomics is the study of all epigenetic changes (DNA modifications and histone modifications) in an organism. Currently, most studies have reported various epigenetic modifications are associated with the pathological process of cancer. Thus, researches on epigenome open a novel sight into the tumorigenesis.
Creative Biolabs is a biotechnology company that is engaged in providing optimal gene sequencing solutions for cancer research. Leveraging our expertise in epigenetics, Creative Biolabs is uniquely positioned to provide a full spectrum of high-quality epigenomic sequencing and analysis services.
Introduction of Epigenomics
Epigenomics is a quickly growing branch of genomics focusing on the study of a series of epigenetic modifications that affect gene activity and expression without altering the DNA sequence. Epigenetic modifications are reversible and heritable, which are involved in various cellular processes such as differentiation/development and tumorigenesis. DNA methylation and histone modification are two of the most characterized epigenetic modifications, which has been revealed an association with the pathogenesis of cancer. Therefore, it is very significant to investigate the epigenetic modifications for a better understanding of the mechanism of tumorigenesis.
What Can We Do in Epigenomics Research
Our professional scientists have accumulated extensive experience in epigenomics research. We provide a comprehensive epigenome sequencing services to address your concerns. Our services include but are not limited:
WGBS is used to identify the DNA methylation status of single cytosines by treating the DNA with sodium bisulfite before sequencing. It offers an effective and reliable strategy for the identification of individual methylated cytosines on a genome-wide scale.
RRBS is an enhanced bisulfite-based sequencing method that is used for analyzing the genome-wide methylation profiles on a single nucleotide level. This technique combines restriction digestion specific to the CpG motifs and bisulfite sequencing to enrich genomic regions with high CpG content, avoiding the cost of whole-genome sequencing.
Targeted methylation sequencing is to study the methylation status of select known differentially methylated regions. This method is widely used for hypothesis testing of the interested target regions as well as verification of the regions identified in genome-wide methylation analyses such as reduced representation bisulfite sequencing, whole-genome bisulfite sequencing, and methylated DNA immunoprecipitation sequencing.
ChIP-sequencing (ChIP-Seq) combines ChIP assays with sequencing to identify genome-wide DNA binding sites for transcription factors and other proteins. It provides an advantageous tool for studying protein-DNA interactions.
Assay for transposase-accessible chromatin using sequencing (ATAC-seq) is a fast and sensitive technique that enables the genome-wide profiling of chromatin accessibility. It detects nucleosome-free regions of the genome by using the Tn5 transposome.
FFPE tissues are invaluable material for profiling gene expression and studying a variety of diseases. But the high-quality nucleic acid samples are difficultly achieved from FFPE tissues because the fixation and subsequent tissue storage methods often cause DNA-protein crosslinks and nucleic acid fragmentation. Creative Biolabs can provide a variety of epigenomic sequencing solutions to assist your epigenomic research for FFPE tissue.
- Various flexible solutions for epigenomics analysis
- Accurate and fast data delivery
- Dedicated team assigned to your project
- Cost and time-saving benefits for your project
Creative Biolabs is your reliable partner in the field of epigenomics research. We provide a full range of flexible solutions for epigenomics analysis. Please contact us for more information and a detailed quote.
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