Anti-Human NY-ESO-1 (c58c61) TCR (HLA-A*0201/SLLMWITQC) Lentivirus Packaging Kit (XS-0622-YF192)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This kit provides a complete lentivirus packaging system to produce anti-NY-ESO-1 (c58c61) TCR lentivirus, which enables TCR-T cells generation to target NY-ESO-1. It contains plasmids that express all the viral proteins necessary, and TCR detection reagent, providing a full set of reagents for TCR lentivirus packaging and TCR expression evaluation. The expressed anti-NY-ESO-1 TCR lentiviruses are HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells. These viruses constitutively express the TCR restricted to HLA-A*0201/SLLMWITQC(157-165). TCR detection reagent can be used to detect the positive expression rate of TCR-T cells after lentiviral transduction.

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Description

Target
NY-ESO-1

Components
This kit contains a TCR lentiviral vector, packaging vectors, TCR detection reagent, and 293 cells.
1. A TCR lentiviral vector
• Anti-NY-ESO-1 (c58c61) TCR plasmid
2. Three packaging vectors
• LentiArt™ pHelp1
• LentiArt™ pHelp2
• LentiArt™ pHelp3
3. TCR detection reagent
4. 293 cells

Size
10 reactions; 20 reactions; 50 reactions

Storage Conditions
For details of the storage requirements, please see the User Manual for instructions.

Applications
TCR lentivirus packaging; TCR lentivirus transfection; TCR-T cell development; TCR-T cell therapy.

TCR Vector

MHC Allele
HLA-A*0201

Peptide
SLLMWITQC

Epitope
157-165

Vector Name
pCDCAR1

Vector Length
~8kb

Vector Type
Lentiviral vector

TCR Construction
TCR alpha-P2A-TCR beta

Target

Gene Name
CTAG1A

Full Name
cancer/testis antigen 1A

scFv
c58c61

Host Species
Human

Target Species
Human

Gene ID
246100

Uniprot ID
P78358

Target Background
The protein encoded by this gene is a tumor cell antigen found in various types of cancers, which makes it a good candidate for a cancer vaccine. This gene is also highly expressed in normal ovary and testis tissues. An identical copy of this gene is found on the same chromosome.

Synonyms
ESO1; CT6.1; LAGE-2; LAGE2A; NY-ESO-1; CTAG1A; Cancer/testis antigen 1A

Related Disease
Melanoma

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-Human NY-ESO-1 (c58c61) TCR (HLA-A*0201/SLLMWITQC) Lentivirus Packaging Kit (XS-0622-YF192)

Description

TCR Vector

Target

Customer Reviews and Q&As

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