All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The vector of anti-CD70 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human CD70. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD70 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Renal cell carcinoma.
CAR Construction : CD70-16D_CC-41BB-CD3ζ Fig.1 In vitro cytotoxicity of CAR cells. Four-hour 51Cr cytotoxicity assays of TanCAR-T cells against tumor cells expressing CD70 and/or B7-H3, compared with CD70 CAR, B7-H3 CAR and NT T cells. Yang, M., Tang, X., Zhang, Z., Gu, L., Wei, H., Zhao, S., ... & Tong, A. (2020). Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors. Theranostics, 10(17), 7622. |
CAR Construction : CD70-16D_CC-41BB-CD3ζ Fig.2 Determination of cytokines release. ELISA results showed the IFN-γ and IL-2 secretion levels by TanCAR, B7-H3 CAR, CD70 CAR and NT T cells encountering multiple tumor cells. Yang, M., Tang, X., Zhang, Z., Gu, L., Wei, H., Zhao, S., ... & Tong, A. (2020). Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors. Theranostics, 10(17), 7622. |
CAR Construction : CD70-16D_CC-41BB-CD3ζ Fig.3 Antitumor response of CAR-T cells in human subcutaneous xenograft models. NCI-H460.ffLuc or A375.ffLuc tumor bearing mice were adoptively transferred through tail vein injection with NT, CD70 CAR, on 7 days and 10 days post tumor inoculation. Yang, M., Tang, X., Zhang, Z., Gu, L., Wei, H., Zhao, S., ... & Tong, A. (2020). Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors. Theranostics, 10(17), 7622. |
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