anti-MAGEA3 TCR, pLXSN(TCR-L061)

The vector of anti-MAGEA3 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MAGEA3. The T cells are genetically modified through transduction with a retroviral vector expressing MAGEA3-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.


Details


Target
MAGEA3 (MAGEA3)
Target Species
Human
Epitope
EVDPIGHLY
Format
Affinity enhanced
HLA
HLA-A1
Targeting Diseases
Melanoma
Vector Name
pLXSN
Vector Length
6714-6688bp
Vector Type
retroviral vector
Antibody Host
Mouse

Target


Gene Name
MAGE family member A3
Official Symbol
MAGEA3
Gene ID
UniProt ID
Synonyms
MAGEA3; Cancer/Testis Antigen Family 1, Member 3; Cancer/Testis Antigen Family 1; MAGE3; MAGEA6; Antigen MZ2-D; Melanoma-Associated Antigen 3; Melanoma Antigen Family A, 3; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Introduction
This gene is a member of the MAGEA gene family. The members of this family encode proteins with
50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show
considerable variability, suggesting that the existence of this gene family enables the same function
to be expressed under different transcriptional controls. The MAGEA genes are clustered at
chromosomal location Xq28. They have been implicated in some hereditary disorders, such as
dyskeratosis congenita.
Alternative Names MAGEA3; Cancer/Testis

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Carcinoma

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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