Close

Biotinylated Human CD22 CAR Detection Reagent (CARD-LX072)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Product has been developed for the detection of transduced T cells that are engineered to express CD22-specific chimeric antigen receptor (CAR) on the cell surface, which recognize human CD22 antigen.The product is an antigen based detection reagent conjugated to biotin. It contains a recombinantly expressed fusion protein consisting of the human CD22 extracellular domains and a specifically mutated human IgG1 Fc region.The engineered CD22 CAR T cells can be detected via the recognition of the CD22 protein, and identified by flow cytometry via anti-biotin fluorochromes.

Specific Inquiry

  • Size:
  • Form:
  Add to Cart

Specifications

  • Target
  • CD22
  • Application
  • FC
  • Storage
  • Store protected from light at 2-8 °C.
  • Application Notes
  • FC: 1:50
  • Diseases
  • Leukemia, B-Cell lymphoma
  • Conjugation
  • Biotin
  • Size
  • 0.06 mL
  • Host Species
  • Human
  • Species Reactivity
  • Human
  • Form
  • Liquid

Target

  • Target Introduction
  • B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
  • Target Alternative Names
  • CD22 Molecule
  • Entrez Gene ID
  • 931

Customer Reviews and Q&As

There are currently no customer reviews or questions for Biotinylated Human CD22 CAR Detection Reagent (CARD-LX072). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Online Inquiry

For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Key Updates
Newsletter NEWSLETTER

The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders

LEARN MORE NEWSLETTER
New Solution NEW SOLUTION

CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.

LEARN MORE SOLUTION
NOVEL SOLUTION NOVEL TECHNOLOGY

Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.

LEARN MORE NOVEL TECHNOLOGY
NEW TECHNOLOGY NEW SOLUTION

Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.

LEARN MORE SOLUTION
Receive our latest news and insights.