Biotinylated Human CD70 CAR Detection Reagent, His,Avitag™,Flag Tag (CARD-LX159)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. Biotinylated Human CD70 CAR Detection Reagent, His,Avitag™,Flag Tag is a special detection reagent which is used to detect Human CD70 CAR related to the study of non-Hodgkin lymphoma (NHL), Hodgkin disease, and multiple myeloma.

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Specifications

Target
CD70

Application
FC, ELISA

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
non-Hodgkin lymphoma (NHL), Hodgkin disease, and multiple myeloma

Molecular Characterization
It contains AA Ser 52 - Pro 193 (Accession # P32970-1)

Conjugation
Biotinylated

Size
200ug

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Form
lyophilized

Target

Target Introduction
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

Target Alternative Names
CD70 Molecule

Entrez Gene ID
970

UniProt ID
P32970-1)

Related Resources

Overview of CD70-Targeted CAR Cell Therapies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Biotinylated Human CD70 CAR Detection Reagent, His,Avitag™,Flag Tag (CARD-LX159)

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Specifications

Target

Related Resources

Customer Reviews and Q&As

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