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Overview
Mature T cell and natural killer (NK) cell neoplasms are rare tumors that result from clonal proliferation of mature post-thymic lymphocytes, which make up about 10 to 12% of all lymphoid cancers. The diseases are usually diagnosed in adults with a age ranging from 17 to 90, and in the total population of this group, men, more than women are manifest to develop these neoplasms. The World Health Organization classifies this group of disorders into NK/T cell lymphoma, nasal type (NKTCL), aggressive NK-cell leukemia (ANKCL) and chronic lymphoproliferative disorders of NK-cells. As a group of biologically and clinically heterogeneous disorders, most NKTCL is exclusively extranodal with the nose and nasopharynx as its common initial sites, whereas ANKCL manifests to be a systemic disease with multiorgan involvement and rapidly evolutes to death.
Signs, symptoms and treatments
Nasal NKTCL patients present symptoms like mass, obstruction swelling, or bleeding, while the ANKCL population shows fever and other extreme systemic symptoms, such as hepatosplenomegaly, pancytopenia and abnormal liver function. Systemic chemotherapy is still the major treatment for unspreaded NK/T-cell lymphomas, but the hematopoietic stem cell transplantation hasn't been prospectively evaluated. Meanwhile, combined chemotherapy-radiotherapy and combination of chemotherapy are also the current treatment strategies depending on the grade and symptoms of the disease.
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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