Human Her2 CAR Detection Reagent, Fc Tag (FITC) (XS-0423-LX42)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Human Her2 CAR Detection Reagent, Fc Tag (FITC) is applied for evaluating Human Her2 CAR expression, and is suitable for FC application.

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Specifications

Target
Her2

Organism
Human

Application
Used for evaluating CAR expression

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.

Shelf-Life
Stable as supplied until expiry date on label.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
Breast cancer

Molecular Characterization
The CAR detection reagent contains AA Thr 23 - Thr 652 of Human Her2.

Conjugation
FITC

Size
25 tests; 100 tests

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Expression
HEK293 cell

Host Species
Human

Species Reactivity
Human

Form
Lyophilized

Target

Target Introduction
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligandbound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinasemediated activation of downstream signalling pathways, such as those involving mitogenactivated protein kinase and phosphatidylinositol3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Target Alternative Names
erb-b2 receptor tyrosine kinase 2

Entrez Gene ID
2064

UniProt ID
P25092-1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.