Anti-CEA T cell receptor (Affinity enhanced), pCDTCR1(TCR-C035Z)

The vector of anti-CEA T cell receptor (TCR) is constructed for the engineering of T cell to target Human CEA. The T cells are genetically modified through transduction with a lentiviral vector expressing CEA-specific T cell receptor. And the vector product was designed for the treatment of Colorectal cancer.


Details


Target
CEA
Target Species
Human
Epitope
IMIGVLVGV
Format
Affinity enhanced
HLA
HLA-A*0201
Targeting Diseases
Colorectal cancer
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Host
Mouse

Target


Gene Name
carcinoembryonic antigen related cell adhesion molecule 5
Official Symbol
CEACAM5
Gene ID
UniProt ID
Synonyms
CEA; CD66e; CEACAM5; carcinoembryonic antigen related cell adhesion molecule 5
Introduction
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products


CarcinomaOthers

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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