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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
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Fluorescence/chromogen-based immunohistochemistry (IHC) provides an important and widely used tool for researchers and pathologists to image multiple Biomarkers in tissue specimens. Multiplex IHC (mIHC) is a powerful investigative tool and can be used to assess the immune context of a tumor. With an experienced team of in-house multiplex IHC experts, Creative Biolabs has developed a consultative strategy to provide our clients with highly customized solutions. From project design to in-depth image analysis, our seasoned scientists will work with you to develop a complete solution for your biomarker development needs.
IHC is widely used to determine the structural organization of biomolecules at the tissue, cellular, and subcellular levels. In oncology, IHC can be used to diagnose, classify into subtypes, and determine the optimal treatment of various cancers, which are of prognostic value. IHC analyses are generally performed on tissue samples, for example, those collected by biopsy or the surgical resection of a tumor. Protein expression of biomarkers in cancer tissue is routinely assessed by IHC and relies on the visual and semiquantitative evaluation of staining patterns and intensity. IHC is easy to perform and does not require advanced or expensive equipment, making it accessible to almost every laboratory. The study of biomarkers has been greatly facilitated by IHC. However, for high-throughput studies of the majority of biomarkers, there are some limits, such as time-consuming and poor flexibility. mIHC combining with multispectral imaging and digital image analysis is an alternative method that can address many of these problems. mIHC is based on the interrogation of multiple antigens on the same tissue section and multispectral imaging enables unmixing of several different spectra, providing the basis for more precise and objective quantification of protein expression.
Fig.1 IHC markers in the pancreatic ductal adenocarcinoma (PDAC) mIHC panel to study tumor immune interactions. (Fassler, 2020)
mIHC is an extremely valuable tool for assessing protein and receptor expression in tissue samples. Therefore, it is an efficient approach for biomarker discovery. Scientists at Creative Biolabs are experts at immunolabeling and will start a project with any antibody. We offer standard mIHC for the identification of 1-5 biomarkers. Moreover, we provide an automated and cost-effective solution for multiplex analysis of up 25 immune markers on a single FFPE slide. Our mIHC antibody panels have been validated in a range of tissues, such as skin, lung, brain, pancreas, breast, and bone marrow tissue. For those looking for digitized images and quantitative analysis, we will scan and process your whole-slide images.
Our professional technical scientists and abundant experience make Creative Biolabs a perfect partner to help our clients in their meaningful biomarker development projects. For more information on our multiplex IHC assay, please feel free to contact us and further discuss with our scientists.
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