Technologies for Immune Monitoring

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Creative Biolabs is committed to providing overall solutions for biomarker discovery, focusing on innovative research. Our scientists have developed a novel methodology for In Silico Biomarker Discovery by facilitating the integration and analysis of public data and private data for the early identification of novel disease-related biomarkers. Additionally, our comprehensive portfolio provides a variety of technologies designed to help researchers in the discovery of biomarkers for Immune Monitoring. We are glad to serve our global clients with professionalism and expertise. Please feel free to contact us for a detailed quote and further discussion with our scientists.

A Wealth of Technologies Are Available for Immune Monitoring at Creative Biolabs

Immunoscore Assay

Based on quantification by digital pathology of CD3⁺ and CD8⁺ cytotoxic T cells in tumor tissues, immunoscore assay is a standardized immune assay to accurately prognosticate colorectal cancer (CRC). Adding Immunoscore to a model combining all clinical variables significantly improves the accuracy of prognosis. Creative Biolabs is versed in Immunoscore assay for CRC.

Protein Microarray

Protein microarrays are a high throughput technology for biomarker discovery. Creative Biolabs has extensive experience in applying protein microarrays for biomarker discovery. Our scientists are proud to address the scientific and technical challenges in biomarker development for immune monitoring.

Gene Expression Microarray

Gene expression microarray is a powerful approach for immune biomarker discovery in high throughput format. Creative Biolabs is proficient in applying gene expression microarray analysis technologies for the identification of potential cancer biomarkers.

RNA Sequencing (RNA-seq)

RNA-seq provides unprecedented resources and opportunities for cancer biomarker discovery. Creative Biolabs has performed many RNA-seq analysis projects during the past few years. We continue to serve our global clients with professionalism and expertise in employing RNA-seq for immune biomarker discovery.

Circulating Tumor DNA (ctDNA) Analysis

ctDNA has emerged as a promising biomarker for monitoring the disease status of cancer patients. Creative Biolabs has pioneered nucleic acid assay-based ctDNA analysis and next-generation sequencing (NGS) based ctDNA for biomarker discovery.

Microsatellite Instability (MSI) Analysis

MSI is an emerging predictive and prognostic biomarker for immunotherapy response in cancer. Creative Biolabs is pleased to share our cutting-edge technology for MSI analysis, including immunohistochemistry (IHC)-based MSI testing, PCR-based MSI testing, and NGS-based MSI testing.

T Cell Receptor (TCR) Repertoire Analysis

TCR repertoire is a source of biomarkers for immune monitoring. Creative Biolabs has accumulated extensive experience in TCR repertoire analysis, including TCR repertoire analysis at the single-cell level. Our scientists are dedicated to serving every unique need of our clients in biomarker development.

High-throughput SNP Genotyping

Creative Biolab has developed several single-nucleotide polymorphism (SNP) genotyping technologies, such as NGS, array-based technologies, real-time PCR, and Sanger sequencing, depending on the species, the number of SNPs per sample, applications, and purpose.

Tumor Mutational Burden (TMB) Analysis

TMB emerges as a promising prognostic and predictive biomarker in multiple diseases for immune monitoring. Creative Biolabs has accumulated extensive experience in employing whole-exome sequencing (WES) and targeted NGS panels for TMB biomarker discovery.

Tumor Neoantigen Analysis

Neoantigens arise from any genomic mutation altering protein sequence. They may play an essential role in tumor rejection. Combining WES and transcriptome sequencing with our optimized bioinformatics analysis, Creative Biolabs provides a comprehensive analysis of candidate neoantigens.

Enzyme-linked Immunosorbent Assay (ELISA)

Scientists at Creative Biolabs are experts in performing indirect ELISA, sandwich ELISA, competitive ELISA, and digital ELISA for biomarker identification to monitoring immune responses.

Enzyme-linked Immunosorbent Spot (ELISpot) Assay

ELISpot is not only a potency assay to assess immune response, but also a biomarker of therapeutic efficacy. Creative Biolab offers high-quality immuno-enzymatic ELISpots and fluorescent ELISpot assay to monitor the immune response.

Flow Cytometry

Flow cytometry is a powerful tool for biomarker discovery to assess immunotherapies by immune monitoring. Creative Biolabs has developed a powerful high throughput flow cytometry platform in 96- and 384-well assay format for biomarker discovery with high sensitivity and high flexibility.

Multiplex Immunohistochemistry (mIHC)

mIHC is an extremely valuable tool for biomarker discovery in tissue samples. Therefore, it is an efficient approach for biomarker discovery. Creative Biolabs has rich experience in performing mIHC assay for biomarker discovery.

Neutrophil-to-lymphocyte Ratio (NLR) Analysis

Peripheral blood NLR has been used as a guide to prognosis in many diseases. This ratio may serve as a useful prognostic biomarker for immune monitoring. With an experienced team of experts in NLR analysis, our seasoned scientists are proficient at NLR analysis and we are happy to work with you to assess the clinical value of this ratio.

Mass Spectrometric Imaging (MSI)

MSI is a technique that provides the opportunity to investigate tumor biology from an entirely novel biochemical perspective and could be used to identify a new pool of cancer biomarkers. Creative Biolabs is experienced in employing MALDI MSI for biomarker discovery.

Reference

Yong, Y.K.; et al. Immune biomarkers for diagnosis and treatment monitoring of tuberculosis: current developments and future prospects. Frontiers in microbiology. 2019, 10:2789.