Get a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
CAR-B cells represent a transformative shift in cellular immunotherapy, harnessing the power of B lymphocytes in the fight against cancer. Unlike CAR-T cells, which are engineered from T lymphocytes, CAR-B cells originate from B lymphocytes, offering distinct advantages in targeting and modulating the immune response.
Fig.1 Chimeric antigen receptor (CAR) and CAR-B cell.
Creative Biolabs has developed a range of CAR-B vectors, each meticulously designed to empower B cells with enhanced specificity and functionality. These vectors are engineered to express CARs on the surface of B cells, enabling them to recognize and target cancerous cells with precision.
CAR Design for CAR-B Cells
One of the key challenges in CAR-B cell therapy is designing CAR constructs that effectively activate and modulate B-cell responses. Creative Biolabs has devised innovative solutions to optimize CAR design specifically for CAR-B cells:
Our expert team at Creative Biolabs carefully selects the antigen-binding domain of CARs, ensuring high-affinity binding to target antigens present on cancer cells. This meticulous design minimizes off-target effects and maximizes therapeutic efficacy.
Customized signaling domains play a pivotal role in CAR-B cell activation. We strategically incorporate signaling domains that amplify B-cell signaling pathways, resulting in potent anti-tumor responses.
To further enhance CAR-B cell functionality, Creative Biolabs has developed CAR constructs that promote the secretion of immunomodulatory cytokines. This feature not only stimulates immune responses but also creates a favorable microenvironment for sustained anti-cancer effects.
Customization for Specific Needs
At Creative Biolabs, we understand that each patient and disease present unique challenges. Our commitment to personalized medicine drives us to offer a wide range of customized services in the field of CAR-B cell therapy:
We excel in the production of patient-specific CAR-B cells, tailored to match the individual's immune profile and the specific cancer antigen. This approach minimizes the risk of graft-versus-host disease and enhances therapeutic outcomes.
Our team of experts is adept at optimizing CAR constructs for maximum efficacy. We fine-tune CAR designs based on the latest research findings and clinical data, ensuring that our CAR-B cell therapies remain at the forefront of innovation.
Creative Biolabs provides comprehensive preclinical and clinical support for CAR-B cell therapy development. Our services encompass in vitro and in vivo studies, safety assessments, and regulatory guidance to expedite the translation of CAR-B cell therapies from bench to bedside.
Contact us today to explore how our tailored solutions can drive your research and therapeutic endeavors forward, bringing us one step closer to unlocking the full potential of CAR-B cell therapy.
We have developed a proprietary online system for customizing CAR and CAR cell products, which offers full options to meet all unique needs, including but not limited to conventional or unconventional CAR constructs, as well as a variety of vectors and cells. The customization process can be completed with just a few simple clicks, please feel free to try it out.
NEWSLETTER
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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