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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Lipid Nanoparticles (LNPs)-Mediated CAR mRNA Delivery
Unlike genetic transformation methods with plasmid or viral vectors, in vitro transcription (IVT)-mediated transient expression of CAR mRNA is safer in cancer immunotherapy. Since the naked mRNA has a short half-life, drug delivery systems such as lipid nanoparticles (LNPs) are necessary to protect mRNA from degradation and enhance cellular uptake. Creative Biolabs has established a CAR IVT platform to support IVT mRNA & LNP manufacturing. We provide full technical support from project design, sequence optimization, and synthesis, to LNP formulation services. Our scientists will encapsulate mRNA with lipids based on specific requirements.
The advantage of the LNP delivery system:
Fig.1 LNPs-mediated CAR mRNA delivery to human T cells.1
CAR IVT LNP Products and Services
Creative Biolabs proudly offers CAR IVT LNP products and services for mRNA-based CAR therapy research and development. We have a purpose-built LNP delivery system for effective encapsulation of mRNA. Moreover, we have optimized our manufacturing strategy to maximize yields and ensure the efficacy of encapsulation. Our integrated CAR IVT LNP manufacturing workflow streamlines production from gene synthesis to LNP packaging. Our CAR IVT LNP products help save time and streamline your efforts.
For any specific requirements or technological support, please contact us.
Quality Control
To ensure that CAR IVT LNP is properly synthesized and loaded with the intended mRNA, Creative Biolabs will perform standard and customized quality control assays, including:
Manufacturing Workflow
Fig.2 Workflow of CAR IVT LNP manufacture.
Reference
NEWSLETTER
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