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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Natural Killer (NK) cells, innate immune effectors known for their innate cytotoxicity, have emerged as promising candidates for CAR-based immunotherapy. CAR-NK cells are genetically engineered to express chimeric antigen receptors, effectively weaponizing them against specific target antigens, including those found on cancer cells. This approach combines the inherent advantages of NK cells, such as rapid response and tumor-killing capabilities, with the precision of CAR technology.
Fig.1 A diagram depicting the mechanics of healthy cell recognition.1
At Creative Biolabs, we recognize the immense potential of CAR-NK vectors in the therapeutic landscape. Our extensive experience and expertise uniquely position us to provide comprehensive insights into CAR-NK therapy.
CAR Design for CAR-NK Cells
The key to the success of CAR-NK therapy lies in the precise design of Chimeric Antigen Receptors, which confer the desired specificity and potency to NK cells.
Selecting the appropriate target antigen is paramount in CAR-NK design. It defines the specificity of the therapy. Our team at Creative Biolabs meticulously evaluates the target antigen's expression on tumor cells and normal tissues to minimize off-target effects. We employ cutting-edge bioinformatics tools to ensure the highest specificity and minimal toxicity.
The CAR structure plays a pivotal role in CAR-NK cell function. A typical CAR consists of an extracellular antigen-binding domain, a transmembrane domain, and intracellular signaling domains. Our experts excel in tailoring CAR designs to enhance NK cell activation, persistence, and tumor cell killing. We optimize CAR structures for costimulatory domains, signal transduction pathways, and cytokine secretion profiles.
Ensuring the safety of CAR-NK therapy is paramount. Creative Biolabs prioritizes the inclusion of safety switches and control mechanisms in CAR designs. These switches, such as suicide genes or antibody-based off-switches, provide an additional layer of control over CAR-NK cells, allowing for rapid intervention in case of adverse events.
Customized CAR-NK Vector Services
Creative Biolabs takes pride in offering customized CAR-NK vector services to cater to the specific needs of our clients. Our services encompass a wide range of capabilities:
We have developed a proprietary online system for customizing CAR and CAR cell products, which offers full options to meet all unique needs, including but not limited to conventional or unconventional CAR constructs, as well as a variety of vectors and cells. The customization process can be completed with just a few simple clicks, please feel free to try it out.
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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