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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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Types of TCR Constructs
Adoptive transfer of lymphocytes (such as TCR gene-modified T cells) is an attractive and promising strategy for the treatment of malignancies and infectious diseases. To date, there are many compelling published clinical data in TCR-T cell therapies. However, many challenges remain and need to be overcome, for example, TCR mispairing can lead to severe and fatal adverse events. Therefore, safe and efficient T cell-based TCR gene therapies need the introduction of a specific TCR complex to target cell lines without TCR mispairing.
Fig.1 Schematic overview of the various TCR-based constructs.1
Regular TCR Vectors
Developing and manufacturing TCR-T cell therapies consists of various complex procedures. Based on an advanced TCR platform, Creative Biolabs provides a unique one-stop solution for TCR-T cells. We are currently developing rapid cloning and expression vectors for engineering TCR-T cells to achieve efficient integration and stable gene expression in target cells. Utilizing our easy-to-use vectors for expression of specific TCR α and β chains, you can now generate TCR-T cells in a simple fashion to target different tumor antigen families.
Please browse the following TCR vector products we provide, or contact us for a custom TCR service if you do not find wanted products. In addition to regular TCR vectors, we also have AbTCR vectors.
Reference
NEWSLETTER
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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