Protein Microarray for Immune Biomarker Discovery Service

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Creative Biolabs is committed to providing overall solutions for biomarker development for immunologic monitoring, focusing on innovative research. Protein microarray is a powerful technology for biomarker discovery in high throughput format. Our team has extensive experience in applying protein microarrays for biomarker discovery, providing accurate and effective solutions for researchers all over the world.

Protein Microarray: a Useful Tool for Biomarker Discovery

Biomarkers indicate the state of a biological process, differentiating if it is normal or pathological. They are all those molecules that are found in body fluids in low abundance and that are associated with specific health or disease processes. The methodology to establish that a biomarker is good for clinical application is divided into three steps, including discovery, verification and validation. Proteomics has identified several proteins that can act as biomarkers. Protein microarray is one of the advanced techniques in proteomics used for biomarker identification, supporting early diagnosis and Immunologic monitoring. Analysis of microarray data has become a useful tool for the study of different illnesses including all types of cancer.

Fig.1 The general outline of any protein microarray workflow. (Neagu, 2019)

Oncology Diseases-Specific Biomarker Detection by Protein Microarray

Biomarker research and its translation into the clinics have been accelerated by protein microarrays due to the extraordinary capacity for identifying valuable biomarkers in a short period without the requirement of any prior in-depth knowledge into the mechanism of disease progression.

A panel of five serum proteins were significantly expressed in serum of prostate cancer patients.
A set of proteins as biomarker candidates associated with hepatocellular carcinoma
11 proteins have been identified in ovarian cancer
A panel of proteins as biomarker candidates in colon carcinoma cells
A panel of proteins as biomarker candidates have been identified in colon carcinoma cells.
Differentially expressed proteins in B-cell chronic lymphocytic leukemia have been identified which are related to target therapeutics

Protein Microarrays for Biomarker Discovery at Creative Biolabs

Based on our advanced Immunologic Monitoring Platform, Creative Biolabs offers accurate and effective solutions for researchers who are committed to biomarker development for immunologic monitoring. Protein microarray is an efficient strategy for biomarker discovery. At Creative Biolabs, mostly human proximal body fluids, such as plasma, serum, and synovial liquid, are available for analyzing targeted/non-targeted biomarkers by protein microarrays, including antibody microarrays and functional protein microarrays. Our multidisciplinary platform teams work together closely to address the scientific and technical challenges in biomarker development for immunologic monitoring.

Antibody microarrays

Antibodies are printed onto an array surface. Multiplexed affinity reagents are used to detect proteins in complex biological samples. Based on the antibody-antigen interaction, particular or rare analytes can be detected in highly heterogeneous mixtures. Therefore, antibody microarrays are usually used to identify biomarkers that predict a healthy or pathologic condition.

Functional protein arrays

Recombinant proteins are printed onto an array surface. Based on the identification of protein interactions with different molecules, this technology is useful in unbiased high throughput screening of antibody biomarkers for a variety of human diseases.

Highlights

High throughput microarray format
Identify biomarkers with a low amount of serum
Profiling antibody responses
Identifying novel disease-specific protein biomarkers, assisting personalized medicine in oncology
Discover and identify drug target pathways
Mapping protein-protein interactions
A comprehensive set of bioinformatics tools

Scientists at Creative Biolabs are proficient at applying protein microarray technology for biomarker discovery. With proven experience in biomarker discovery, Creative Biolabs is an ideal company to entrust with your business. For more detailed information, please feel free to contact us or directly send us an inquiry.

Reference

Neagu, M.; et al. Protein microarray technology: assisting personalized medicine in oncology. World Academy of Sciences Journal. 2019, 1(3):113-24.