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TS-IL15 SA Anti-MAGE-A4 (XW-636) BBζ CAR (XS-0822-YF10199)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Mouse MAGE-A4 chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-IL15 SA-EF1a-scFv-41BB-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • MAGE-A4
  • Targeting Diseases
  • Melanoma
  • Generation
  • 2nd-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-IL15 SA-EF1a-scFv-41BB-CD3ζ

Target

  • Clone
  • XW-636
  • Host
  • Rat
  • Target Species
  • Mouse
  • Gene Name
  • Melanoma-associated antigen 4
  • Synonyms
  • MAGEA4; CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A; MAGE4B; MAGE family member A4
  • Introduction
  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Several variants encoding the same protein have been found for this gene.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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