Drug-loaded Nanoparticle based Sonosensitizer Development Service for Advanced Sono-Immunotherapy
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An Innovative Frontier in Oncology from Creative Biolabs
The drug-loaded nanoparticle-based sonosensitizer development service offers advanced cancer treatment, combining sonodynamic therapy (SDT) with immunotherapy. This strategy utilizes nanoparticles for the precise delivery of sonosensitizers and immunomodulators to tumors, or for combining with other treatments. SDT, activated by ultrasound, generates reactive oxygen species, inducing targeted cancer cell death and priming the immune system via immunogenic cell death. Nanoparticles enhance tumor accumulation (EPR) effect, improve drug stability, enable stimuli-responsive release, and facilitate co-delivery of agents like STING agonists. This synergistic approach aims for superior tumor eradication, immunosuppressive microenvironment remodeling, and durable anti-tumor immunity.
The pivotal role of drug-loaded nanoparticles: Drug-loaded nanoparticles offer precise tumor accumulation via EPR, enhancing solubility/stability. They enable controlled, stimuli-responsive release and function as multi-delivery platforms for sonosensitizers, chemotherapeutics, immunomodulators, and gene therapy agents, also overcoming biological barriers like hypoxia.
Workflow
Our comprehensive workflow is meticulously designed to guide your project from initial concept to robust preclinical data, ensuring clarity, efficiency, and scientific rigor at every stage. This structured approach makes the complex process of nanoparticle development transparent and manageable for our clients.
Publication
This publication introduces an injectable, drug-loaded hybrid hydrogel, termed AMPS, designed for combined SDT and chemodynamic therapy (CDT), as well as for suppressing tumor metastasis. The hydrogel is alginate (ALG)-based and incorporates manganese dioxide (MnO2) nanoparticles as CDT agents, an organic polymer as a sonosensitizer, and the drug SIS3 to inhibit metastasis. The AMPS hydrogel forms in the tumor microenvironment through the chelation of ALG by Ca2+. MnO2 nanoparticles facilitate CDT via a Fenton-like reaction, while the organic polymer enables SDT by generating singlet oxygen (1O2) under ultrasound (US) irradiation. Additionally, SIS3 released from the hydrogel works to inhibit the metastasis of tumor cells. This combined approach of SDT and CDT significantly restricts the growth of subcutaneous tumors in mice and effectively suppresses tumor metastasis in the lungs and liver. The study concludes that this hybrid hydrogel platform offers a comprehensive strategy for combinational cancer therapy and simultaneous metastasis suppression.
Fig.1 AMPS hydrogels for SDT-CDT combinational therapy.1
Why Choose Creative Biolabs?
Creative Biolabs is your premier partner for drug-loaded nanoparticle-based sonosensitizer development, backed by nearly two decades in nanomedicine and oncology. Our integrated expertise spans material science, chemistry, drug delivery, and immunology, ensuring holistic development. Projects are custom-designed, precisely engineering nanoparticles for specific therapeutic goals. We offer cutting-edge technologies, including advanced synthesis platforms and robust in vitro/in vivo models, crucial for evaluating immune responses. A core focus is on immunomodulation, leveraging sonodynamic therapy to induce immunogenic cell death and activate immune pathways, transforming "cold" tumors into "hot" ones. Comprehensive biosafety evaluation, from hemolysis assays to systemic toxicity studies, is integrated, ensuring safety and translatability.
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FAQs: Your Questions Answered
Q1: What types of sonosensitizers can be incorporated into your nanoparticles?
A1: Creative Biolabs offers a highly customizable sono-immunotherapy service using a wide range of sonosensitizers, including organic molecules and various inorganic nanoparticles, tailored to your project's specific needs.
Q2: How do your nanoparticles improve drug delivery to tumors compared to conventional methods?
A2: Our nanoparticles enhance tumor drug delivery by exploiting the EPR effect for passive accumulation. Creative Biolabs also functionalizes them with targeting ligands for active delivery and engineers them for stimuli-responsive release (e.g., pH, ultrasound) for precise, on-target payload delivery.
Q3: Can Creative Biolabs' service help overcome tumor hypoxia for better SDT efficacy?
A3: Absolutely. Creative Biolabs counteracts tumor hypoxia in SDT by co-loading oxygen-generating agents. We also design nanoparticles engineered to function effectively in hypoxic conditions, ensuring robust ROS generation and enhanced SDT efficacy.
Customer Review
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Potent Immune Activation.
Creative Biolabs' nanoparticles induced immunogenic cell death and activated the STING pathway, remarkably increasing T cell infiltration in our tumor models. Their exceptional immunomodulation expertise and meticulous immunological assays provided invaluable insights into the immune response. - Prof. S* *th
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Responsive Release Precision.
Creative Biolabs' expertise in TME-responsive drug release nanoparticles, particularly for tumor hypoxia, was invaluable. Their FA-targeted, GSH/H2O2-responsive system showed superior efficacy and a strong safety profile, offering a promising platform for future therapeutic development. - Dr. P* *rk
Related Services
To complement your advanced sono-immunotherapy research, Creative Biolabs offers a comprehensive suite of related services designed to accelerate your drug development pipeline and provide holistic support for your oncology projects:
ICD Induction Service
Inducing immunogenic cell death (ICD) boosts cancer immunotherapy, a breakthrough strategy to overcome limited success in solid tumors and enhance treatment outcomes.
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DCs-Involved Immuno-Oncology Models
Dendritic cells (DCs) bridge innate and adaptive immunity, promoting anti-tumor responses through T-cell interaction. This makes them crucial targets for cancer drug development, enhancing the body's natural defenses.
Learn More →
How to Contact Us
Ready to revolutionize your cancer therapeutic development with a partner who understands your needs? Contact our expert team at Creative Biolabs today to discuss your specific project requirements, explore customized solutions, and receive a detailed quote tailored to your research goals.
Get Started: Contact Us.
Reference
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Yang, Mengyao, et al. "Nanomaterials enhanced sonodynamic therapy for multiple tumor treatment." Nano-Micro Letters 17.1 (2025): 157. Distributed under Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.1007/s40820-025-01666-8
