Immune checkpoints represent a group of membrane proteins expressed on effector cells (e.g., T/B cells and NK cells) that are composed of a variety of co-inhibitory and co-stimulatory pathways. They are involved in eliminating unwanted substances while maintaining their own tolerance, which plays a crucial role in immune regulation.
Generally, there are two types of immune checkpoints: activating receptors and inhibitory receptors. Thus, the two main mechanisms of immunotherapeutic antibodies can be defined as blocking the pathway (antagonists) and enhancing the pathway (agonists). To thoroughly validate the mechanism of action of these antibodies, Creative Biolabs has combined a range of cell-based assays with our state-of-the-art technology and in-depth knowledge in the field to provide a full range of immune checkpoints assay approaches for antibody functional characterization.
Inhibitory Immune Checkpoints | Stimulatory Immune Checkpoints | ||||||||||||||||||||||||||||||||||||
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We can help our clients design a roadmap that begins with the screening and analysis of the selected candidates, performs interaction analysis with the selected candidates, and then progresses to the analysis of the immunomodulatory function. Through this roadmap, we can demonstrate the binding and functional properties of antibodies and their underlying mechanisms of action.
For more details, please feel free to contact us or send us a query directly.
For Research Use Only | Not For Clinical Use