Immuno-oncology Assays

In the search for accurate cancer treatment, scientists are developing new technologies, known as immuno-oncology, that use the body's natural defenses to target and eradicate cancer cells. Over the past decade, immuno-oncology has become an exciting new approach to cancer treatment due to its specificity, adaptability and durability.

However, the development of new immunotherapies still faces many challenges. Proper tools are needed to accurately track the dynamic interactions of immune cells and tumor cells in this highly complex tumor microenvironment.

The living cell analysis technology developed by Creative Biolabs is such a tool that can be used for in vitro analysis to study the dynamic interactions between cancer cells and immune cells. We also offer a wide range of assays and platforms for in vitro detection of immunodominant drugs, including immunophenotyping, functional assays and tumor microenvironmental regulation analysis, allowing you to confidently move on to the next phase of drug development.

Immuno-Oncology Assays

In Vitro Immunophenotyping and Cell Profiling

  • FACS and IHC for characterization of immunological oncology agents
  • Immunocyte purification for subset enrichment
  • Cytokine analysis - Luminex analysis, and ELISA / ELISPOT to quantify the frequency of cytokine-producing cells
  • T cell receptor sequencing for biomarker ID and diagnostic development
  • Perform cell proliferation assays with isolated immune cells to assess the cytotoxic potential of your compound

In Vitro Tumor Cell Killing Test

Tumor Target

  • Target expression analysis on a subset
  • Effect on antigen presentation/killing tests
  • Modulation checkpoint ligand expression
  • Tumor-derived immunoregulatory factors
  • Direct cytotoxicity (cancer cell lines)

Immune Cell-mediated Cancer Cell Killing

  • ADCC (antibody-dependent cell-mediated cytotoxicity assay)
  • CDC (complement dependent cytotoxicity test)
  • ADCP (antibody-dependent cellular phagocytosis)
  • T cell killing - LDH determination
  • NK-mediated cell killing assay (based on FACS)

Novel Immuno-oncology Target Identification

We continue to enhance our in vitro immune tumor platform to provide biochemical and cell-based screening assays for novel immunotherapies. To find out more about our in vitro immuno-oncology services, please contact us.

For Research Use Only | Not For Clinical Use

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