Accelerate Your Drug Development with Unmatched Translational Fidelity!

Are you grappling with prolonged drug development cycles, or unpredictable human immune responses? Creative Biolabs' African Green Monkey delivers clinically predictive insights through immune system mirroring, and human-like metabolic pathways. Leverage our ethically sourced African Green Monkey, advanced genomic profiling to streamline preclinical validation and de-risk therapeutic candidates.

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Key Advantages

The African Green Monkey (AGM) serves as an exceptional translational model due to its distinctive biological strengths:

• Genetic & Immunological Similarity: With 92-94% of genes and preserved immune pathways akin to humans, AGMs accurately simulate human reactions to biologics, vaccines, and gene therapies.
• Neurological Significance: Their neuroanatomy and blood-brain barrier characteristics make them highly suitable for central nervous system drug development.
• Metabolic Accuracy: AGM cytochrome P450 enzymes closely resemble those in humans, providing reliable pharmacokinetic and pharmacodynamic data.
• Infectious Disease Modeling: Naturally prone to HIV/SIV and various human pathogens, AGMs are indispensable for antiviral and vaccine research.

Applications in Drug Discovery & Development

AGMs enable end-to-end preclinical validation across five key domains:

1. Toxicology & Safety Pharmacology: Conduct repeat-dose studies with human-predictive toxicity profiles.

2. PK/PD & Dose Optimization: Map drug absorption, distribution, and clearance using AGM-specific metabolic assays.

3. Complex Disease Models: Study neurodegenerative (Alzheimer's, Parkinson's), infectious (HIV, Ebola), and metabolic disorders (diabetes) with high clinical correlation.

4. Biologics & Advanced Therapies: Evaluate monoclonal antibodies, CAR-T cells, and AAV vectors for immunogenicity and efficacy.

5. Vaccine Development: Assess immunogenicity and protective efficacy against emerging pathogens.

Available Biological Samples

Access ethically sourced, SPF-certified AGM samples to power your research:

AGM In Vivo Research Services

Creative Biolabs provides comprehensive AGM-based solutions, encompassing:

• Toxicology & Safety Assessments: Utilize studies adhering to standardized laboratory practices.
• Immunogenicity Profiling: Assess anti-drug antibody (ADA) and neutralizing antibody reactions for biologic therapies.
• Neurodegenerative Disease Models: Employ validated models for Parkinson's and Alzheimer's to test therapeutic efficacy.
• High-Resolution Bioanalysis: Measure biomarkers, drug levels, and gene expression using techniques such as LC-MS/MS and RNA sequencing (RNA-seq).

Rigorous Quality & Animal Care

Our AGM platform ensures data integrity and ethical rigor:

• Ethical Sourcing: Colonies with full traceability.
• SPF Health Monitoring: Quarterly PCR screening for 20+ pathogens (e.g., SIV, TB).
• Veterinary Excellence: 24/7 care by boarded veterinarians.
• Regulatory Mastery: GLP-certified facilities.

Contact Us

With over two decades of expertise, we specialize in AGM models for studying neurodegenerative and infectious diseases, providing comprehensive solutions from sample procurement to regulatory assistance. Engage in expedited consultations with our scientists within 48 hours. Reach out to us today to revolutionize your preclinical strategy.