Revolutionize Your Neurological Drug Development!

Are you grappling with the lack of predictive neurobehavioral models or translational gaps in central nervous system (CNS) therapies? Creative Biolabs' Capuchin Monkey addresses these challenges by leveraging cognitive-behavioral homology and sophisticated neurogenetic profiling. Our models facilitate accurate assessment of drug efficacy, neurotoxicity, and intricate behavioral outcomes, supported by an 85% alignment with human brain structures for CNS-focused therapeutics and employing tool-using behavioral paradigms to investigate cognitive disorders such as Alzheimer's and autism.

Distributed under CC BY-SA 3.0, from Wiki, without modification.

Key Advantages

Capuchin monkeys exhibit unique advantages for neuropharmacology and immunology:

• Cognitive Homology: 79g brain mass with prefrontal cortex development mirroring humans, enabling unparalleled neurobehavioral studies.
• Genetic Alignment: 88% homology in drug-metabolizing enzymes (CYPs) and blood-brain barrier transporters.
• Immune Precision: T-cell receptor diversity overlaps with humans by 82%, ideal for neuroinflammatory and autoimmune disease modeling

Applications in Drug Discovery & Development

Capuchin monkeys excel across five critical domains:

1. Neurotoxicology: Predict CNS adverse effects (e.g., neurodegeneration, seizures) with 92% human response correlation.
2. PK/PD Modeling: Validate brain penetration and pharmacokinetics using in vivo blood-brain barrier models.
3. Neurological Disease Models:
   • Alzheimer's: Amyloid-beta plaque progression tracked via non-invasive CSF biomarkers.
   • Parkinson's: Dopaminergic pathway analysis using motor task performance metrics.
4. Biologics Evaluation: Assess monoclonal antibodies, gene therapies (AAV9), and CAR-T cells in neuroimmune interfaces.
5. Vaccine Development: Model cognitive outcomes of viral CNS infections (e.g., Zika, neurotropic influenza)

Capuchin Monkey In Vivo Research Services

• Neurobehavioral Toxicology: Studies integrating Morris water maze and operant conditioning tasks.
• CNS Pharmacokinetics: Multiplexed LC-MS/MS analysis of drug concentrations in CSF and brain parenchyma.
• Immunogenicity Profiling: ADA/Nab detection for biologics crossing the blood-brain barrier.
• Disease Models: Induced Parkinson's (MPTP), Alzheimer's (Aβ42 infusion), and neuropsychiatric syndromes.

Rigorous Quality & Animal Care

• SPF Health Condition: Our colony sustains a strictly monitored Specified Pathogen-Free status, ensuring they remain free from critical pathogens (Herpes B, SIV, and Zika virus).
• Holistic Animal Welfare: We adhere to global animal welfare standards, executing comprehensive enrichment programs to uphold animal well-being.

Contact Us

Drawing upon substantial experience in preclinical drug discovery and development using non-human primates (NHPs), our platform acts as your comprehensive partner. We offer an extensive range of products and specialized services, providing top-tier, predictive insights across the entirety of your research and development journey. For further information on how our expertise can assist your project, please feel free to get in touch with us.