The Cynomolgus Monkey (Macaca fascicularis), often referred to as the Cyno or crab-eating Macaque, is the most widely used non-human primate species in preclinical drug development. Its exceptional physiological, genetic, and immunological similarities to humans make it an indispensable model for evaluating the safety and efficacy of novel therapeutics, providing highly predictive data for human trials. Our commitment to ethical sourcing, rigorous health management, and a deep understanding of Cynomolgus Monkey biology ensures you receive the highest quality models for your critical research.

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Key Advantages

Selecting the right NHP species is vital for translational success. Cynomolgus Monkey offer distinct advantages due to their remarkable homology with humans:

• Physiological & Genetic Homology: Their organ systems and genetic makeup (93-95% shared genes) are highly similar to humans. This enables accurate assessment of systemic drug effects and ensures high translational potential.
• Relevant Immunology: With an immune system closely mirroring humans, they're critical for evaluating biologics, vaccines, and cell therapies, allowing for more accurate prediction of human immune responses.
• Predictive Metabolism: Drug-metabolizing enzymes and pathways show strong correlation with humans, leading to highly relevant PK/PD data.

Applications in Drug Discovery & Development

The versatility of the Cynomolgus Monkey supports drug development across various stages and therapeutic areas:

• General Pharmacology & Toxicology: As the primary non-rodent model for toxicology studies, their human-like response patterns are highly predictive for potential adverse effects.
• Pharmacokinetics (PK) & Pharmacodynamics (PD): We use Cynomolgus Monkey for robust PK profiling, bioavailability studies, dose-response evaluations, and understanding drug exposure-response relationships, which are directly translatable to human clinical trials.
• Supported Disease Models: We leverage Cynomolgus Monkey to study complex human diseases, including metabolic (diabetes, obesity, NASH), cardiovascular (hypertension, atherosclerosis), neurodegenerative (Parkinson's, Alzheimer's), and autoimmune (RA, SLE) disorders.
• Biologics & Advanced Therapies: They're essential for evaluating cutting-edge therapeutics like monoclonal antibodies, ADCs, bispecific antibody, gene therapies (AAV, lentivirus), and cell therapies (CAR-T, iPSC-derived cells). We assess their immunogenicity, biodistribution, efficacy, and safety.
• Vaccine Development: They serve as a crucial model for assessing vaccine immunogenicity and protective efficacy against various pathogens.

Available Biological Samples

Access high-quality Cynomolgus Monkey-derived samples to support your research and regulatory needs:

• Blood-derived samples: Whole Blood, Plasma, Serum, PBMCs.
• Other Biofluids: Urine, Cerebrospinal Fluid (CSF), Bronchoalveolar Lavage Fluid (BALF).
• Cells: Hepatocytes, specific Immune Cell Subsets.
• Nucleic Acids: DNA, total RNA, cDNA
• Tissues: Fresh frozen and fixed tissues from various organs.
• Specialty Samples: Exosomes, Subcellular Samples, and AAV Vector Samples.

For detailed specifications, donor information, and ordering, please visit our dedicated products page.

Cynomolgus Monkey In Vivo Research Services

Benefit from our expertise in conducting a full spectrum of preclinical studies utilizing Cynomolgus Monkey:

• Toxicology & Safety Pharmacology: Regulatory-compliant single/repeat-dose toxicity studies and safety assessments for cardiovascular, respiratory, and CNS systems.
• Comprehensive PK/PD Studies: Analysis of drug absorption, distribution, metabolism, and excretion, coupled with pharmacodynamic endpoint evaluations.
• Immunogenicity Assessment: Evaluation of ADA and NAb responses in Cynomolgus Monkey for biologics, gene therapies, and cell therapies.
• Complex Disease Model Studies: Establishment and utilization of models for metabolic, cardiovascular, neurological, autoimmune, and infectious diseases for efficacy evaluation.
• Bioanalysis & Biomarker Detection: High-precision analysis of drug concentrations, biomarkers, immune cell subsets, and gene expression from various biological samples.

Rigorous Quality & Animal Care

We ensure all research and biospecimens meet the highest standards:

• Ethical Sourcing & Traceability: Our animals are ethically sourced, with full adherence to international regulations.
• SPF Health Status: Our colony maintains a rigorously controlled Specified Pathogen-Free status, guaranteeing freedom from key pathogens (e.g., Herpes B virus, SIV, SRV, TB).
• Superior Veterinary Care: An experienced veterinary team provides continuous health monitoring and care.
• Comprehensive Animal Welfare: We follow international animal welfare standards, implementing robust enrichment programs to ensure animal well-being.

Contact Us

With years of experience in NHP-based preclinical drug discovery and development, our platform stands as your one-stop partner. We provide comprehensive products and expert services, ensuring high-quality, predictive insights across your entire R&D journey. If you want to know more about how our expertise can benefit your project, please feel free to contact us.