Transform Your Preclinical Outcomes with Human-Relevant Insights!

Are you struggling with limited predictive power in neurological studies or inefficient vaccine efficacy assessments? Our Squirrel Monkey models bridge the translational gap, offering unparalleled insights into neurodegenerative disorders, vaccine immunogenicity, and advanced therapies. Leveraging their unique neuroanatomical homology and immune system parallels, we deliver human-relevant data supported by cutting-edge genomic profiling.

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Key Advantages

Squirrel Monkeys exhibit 95% genetic homology with humans, particularly in neural pathways and immune signaling, making them indispensable for studies requiring high physiological relevance

• Neurological Precision: Their cortical structure and neurotransmitter systems mirror humans, ideal for Parkinson's, Alzheimer's, and epilepsy research.
• Reproductive Efficiency: Shorter gestation periods 150-170 days, enable rapid colony scaling for large-scale trials.
• Immune Responsiveness: MHC class I/II gene similarity ensures accurate evaluation of vaccines and immunotherapies.

Applications in Drug Discovery & Development

Squirrel Monkeys support five critical domains in preclinical research:

1. Toxicology & Safety: Predictive systemic toxicity profiling.
2. PK/PD Modeling: Human-like drug metabolism for dose optimization.
3. Disease Models: Validated models for metabolic disorders, neuroinflammation, and infectious diseases (e.g., Zika, dengue).
4. Biologics & Cell Therapies: ADA/NAb assessment for monoclonal antibodies, CAR-T cells, and AAV vectors.
5. Vaccine Development: High-resolution immune profiling for efficacy and adjuvant testing.

Available Biological Samples

Squirrel Monkeys In Vivo Research Services

• Neurotoxicity Screens: Conduct assessments to evaluate CNS penetration and identify off-target effects of compounds.
• PK/PD Bridging Studies: Facilitate the connection between preclinical dosing regimens and subsequent human clinical trials through comprehensive pharmacokinetic and pharmacodynamic analyses.
• Immune Profiling: Utilize multiplex cytokine and chemokine panels to assess immune responses in vaccine candidate evaluations.
• Disease Modeling: Develop and customize models for complex diseases such as non-alcoholic steatohepatitis (NASH), Alzheimer's disease, and autoimmune disorders.
• Bioanalytical Support: Provide advanced bioanalytical services including LC-MS/MS quantification, flow cytometry, and RNA sequencing (RNA-seq) to support research objectives.

Rigorous Quality & Animal Care

• SPF Certification: Maintain a SPF status, certifying colonies as free from significant pathogens such as B virus, Simian Retrovirus (SRV), and Tuberculosis (TB).
• Veterinary Excellence: Implement continuous monitoring under the supervision of certified veterinarians, ensuring the highest standards of animal health and welfare.
• Behavioral Well-being: Develop and maintain enrichment programs designed to promote behavioral health and psychological well-being for all animal subjects.

Contact Us

With extensive experience in non-human primate (NHP)-based preclinical drug discovery and development, our platform serves as your all-in-one partner, delivering a full suite of products and expert services to ensure high-quality, predictive insights throughout your research and development journey. To learn more about how our expertise can enhance your project, please feel free to reach out to us. Creative Biolabs' Squirrel Monkey platform offers a pathway to accelerated, human-relevant R&D. Connect with our team to explore tailored solutions.