Unlock Human-Ready Therapeutics with the Ultimate Translational Bridge

Are you struggling with unpredictable clinical translation, high attrition rates in biologics, or complex immunological challenges? Creative Biolabs' Rhesus Macaque platform delivers human-like disease modeling, validated safety assessments, and predictive pharmacokinetics through next-generation bioanalytic, and 10+ years of NHP translational expertise.

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Key Advantages

The Rhesus Macaque (Macaca mulatta) exhibits a 93% genomic similarity to humans, encompassing preserved drug-metabolizing enzymes (CYPs), intricate adaptive immune system features, and neurovascular physiology. Its unique advantages include:

• Neurobiological Fidelity: Critical for modeling Parkinson's, Alzheimer's, and neurodevelopmental disorders, supported by brain activity studies showing human-like decision-making neural dynamics.
• Immune System Reproducibility: MHC class I/II homology enables accurate evaluation of monoclonal antibodies, CAR-T therapies, and vaccine adjuvants.
• Cardiometabolic Relevance: Spontaneously develops atherosclerosis, diabetes, and hypertension, mirroring human disease progression.

Applications in Drug Discovery & Development

Rhesus Macaques support end-to-end preclinical validation:

1. Toxicology & Safety Pharmacology: Generate regulatory-ready data with human-like organ toxicity profiles.

2. PK/PD Modeling: Predict drug absorption, distribution, and clearance using cytochrome P450 homologs and renal filtration systems.

3. Complex Disease Models: Replicate metabolic disorders (NASH, diabetes), neurodegenerative diseases (Parkinson's), and autoimmune conditions (RA, SLE).

4. Biologics & Cell Therapies: Assess monoclonal antibodies, CAR-T cells, and AAV-based gene therapies for immunogenicity and biodistribution.

5. Vaccine Efficacy: Validate antigen-specific T-cell responses and durability against pathogens like HIV and influenza.

Available Biological Samples

Obtain ethically sourced, SPF-certified specimens accompanied by comprehensive COA documentation.

Rhesus Macaque In Vivo Research Services

The Rhesus Macaque (Macaca mulatta) is one of the most extensively utilized and well-established non-human primate (NHP) models in biomedical and preclinical research. Leveraging its high degree of similarity to humans in genetics, physiology, and immunology, the Rhesus macaque provides an indispensable platform for assessing the safety and efficacy of novel therapeutics. Its primary applications encompass the following areas:

• Toxicology & Safety Pharmacology: Used to conduct single-dose and repeat-dose toxicology studies that are compliant with global regulatory agencies. It is also extensively utilized for core battery safety pharmacology assessments of the cardiovascular, respiratory, and central nervous systems to identify potential adverse effects.
• PK/PD Studies: Serves as an ideal model for comprehensive pharmacokinetic (PK) analysis, studying the processes of drug absorption, distribution, metabolism, and excretion (ADME). This is coupled with the evaluation of pharmacodynamic (PD) endpoints to fully elucidate a drug's dose-response relationship and mechanism of action.
• Immunogenicity Assessment: Possessing an immune system that is highly homologous to that of humans, the Rhesus macaque is considered the gold-standard model for evaluating the immunogenicity of innovative therapeutics such as biologics, gene therapies, and cell therapies. It enables the precise detection of anti-drug antibody (ADA) and neutralizing antibody (NAb) responses and their potential impact.
• Pharmacology & Efficacy Evaluation: Plays a pivotal role in the development and application of complex disease models. This is particularly true in fields such as infectious diseases (e.g., the renowned SIV model for AIDS), neurodegenerative disorders, reproductive biology, cardiovascular and metabolic diseases, and autoimmune disorders, providing critical data to support the efficacy evaluation of new drugs.
• Bioanalysis & Biomarker Detection: Supports high-sensitivity and high-precision bioanalysis from a wide range of biological matrices, including blood, cerebrospinal fluid (CSF), and tissue. Capabilities include the measurement of drug and metabolite concentrations, detection of pharmacodynamic and safety biomarkers, analysis of immune cell subsets via flow cytometry, and the quantitative analysis of gene and protein expression levels.

Rigorous Quality & Animal Care

• Ethical Sourcing: CDC-compliant colonies
• SPF Health Monitoring: Quarterly PCR panels for Herpes B, SRV, and SIV
• Veterinary Oversight: 24/7 care with behavioral enrichment protocols

Contact Us

Backed by extensive expertise in preclinical drug discovery and development using non-human primate species, our platform serves as an integrated partner for your research needs. We deliver a full spectrum of products and specialized services, offering reliable and translational insights to support every stage of your R&D pipeline. To learn more about how our capabilities can advance your project, we welcome you to reach out to our team.